ArticleThe Journal of physiology2007
Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 50 citations in OpenAlex.
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- Whole-Cell Patch-Clamp Electrophysiology to Study Ionotropic Glutamatergic Receptors and Their Roles in Addiction.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Layer-specific effects of dopaminergic D1 receptor activation on excitatory synaptic trains in layer V mouse prefrontal cortical pyramidal cells.Physiological reports · 2018Article
- Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex.Frontiers in neuroanatomy · 2018Review
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Article
- Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine Modulation.Journal of Huntington's disease · 2016Review
- Dopamine Receptors and Neurodegeneration.Aging and disease · 2015Review
- Cell-attached single-channel recordings in intact prefrontal cortex pyramidal neurons reveal compartmentalized D1/D5 receptor modulation of the persistent sodium current.Frontiers in neural circuits · 2015Article
- Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.Neurobiology of disease · 2015Article
- Two-photon optical interrogation of individual dendritic spines with caged dopamine.ACS chemical neuroscience · 2013Article
- Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.Journal of neurophysiology · 2013Article
- Dopaminergic modulation of axonal potassium channels and action potential waveform in pyramidal neurons of prefrontal cortex.The Journal of physiology · 2013Article
- Article
- Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates.Frontiers in aging neuroscience · 2013Article
- Levodopa-induced dyskinesia is strongly associated with resonant cortical oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Review
- The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia.Reviews in the neurosciences · 2012Review
- Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Retinal parallel processors: more than 100 independent microcircuits operate within a single interneuron.Neuron · 2010Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine (DA) effects on prefrontal cortex (PFC) neurons are essential for the cognitive functions mediated by this cortical area. However, the cellular mechanisms of DA neuromodulation in neocortex are not well understood. We characterized the effects of D1-type DA receptor (D1R) activation on the amplification (increase in duration and area) of excitatory postsynaptic potentials (EPSPs) at depolarized potentials, in layer 5 pyramidal neurons from rat PFC. Simulated EPSPs (sEPSPs) were elicited by current injection, to determine the effects of D1R activation independent of modulation of transmitter release or glutamate receptor currents. Application of the D1R agonist SKF81297 attenuated sEPSP amplification at depolarized potentials in a concentration-dependent manner. The SKF81297 effects were inhibited by the D1R antagonist SCH23390. The voltage-gated Na+ channel blocker tetrodotoxin (TTX) abolished the effects of SKF81297 on sEPSP amplification, suggesting that Na+ currents are necessary for the D1R effect. Furthermore, blockade of 4-AP- and TEA-sensitive K+ channels in the presence of TTX significantly increased EPSP amplification, arguing against the possibility that SKF81297 up-regulates currents that attenuate sEPSP amplification. SKF81297 application attenuated the subthreshold response to injection of depolarizing current ramps, in a manner consistent with a decrease in the persistent Na+ current. In addition, D1R activation decreased the effectiveness of temporal EPSP summation during 20 Hz sEPSP trains, selectively at depolarized membrane potentials. Therefore, the effects of D1R activation on Na+ channel-dependent EPSP amplification may regulate the impact of coincidence detection versus temporal integration mechanisms in PFC pyramidal neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.