ArticleThe Journal of physiology2007
Where does all the PIP2 come from?
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- From spikes to intercellular waves: Tuning intercellular calcium signaling dynamics modulates organ size control.PLoS computational biology · 2021Article
- Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.PLoS computational biology · 2021Article
- A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.PloS one · 2021Article
- Mathematical Model Predicts Effective Strategies to Inhibit VEGF-eNOS Signaling.Journal of clinical medicine · 2020Article
- Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.Biophysical journal · 2019Article
- Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.British journal of pharmacology · 2017Article
- PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.The Journal of general physiology · 2014Article
- The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Serotonin inhibits low-threshold spike interneurons in the striatum.The Journal of physiology · 2012Article
- HIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage.Molecular biology international · 2012Article
- Combined phosphoinositide and Ca2+ signals mediating receptor specificity toward neuronal Ca2+ channels.The Journal of biological chemistry · 2011Article
- Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.Journal of virology · 2010Article
- Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels.The Journal of general physiology · 2009Article
- Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.The Journal of physiology · 2008Review
- Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Regulation of ion channels and transporters by phosphatidylinositol 4,5-bisphosphate.The Journal of physiology · 2007Article
- Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Despite its very low concentration in the plasma membrane, PIP(2) is the precursor for the important second messenger InsP(3) and, independently, is a key modulator of membrane signalling molecules such as ion channels. However, it has been difficult to determine the spatial and temporal characteristics of PIP(2) and InsP(3) during a cell signalling event. Our laboratory used bradykinin stimulation of N1E-115 neuroblastoma cells to infer the InsP(3) dynamics from calcium imaging studies, biochemical analysis and InsP(3) uncaging. We have used computational modelling with Virtual Cell to help analyse and interpret experimental data on the details of the calcium release process as well as to build a comprehensive image-based model of agonist-induced calcium release in a neuronal cell. These data provided a constraint for the further investigation of how low levels of cellular PIP(2) could provide sufficient InsP(3) for calcium release. Using biochemical assays, quantitative imaging of GFP-based probe translocation and computational analysis, it was shown that PIP(2) synthesis is stimulated concomitant with its hydrolysis. This mechanism should be important not just for consideration of PIP(2) as a precursor of InsP(3), but for any pathway that can be directly or indirectly modulated by PIP(2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.