ArticleJournal of anatomy2007
Revascularization and remodelling of pancreatic islets grafted under the kidney capsule.
Article in Journal of anatomy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates.Cell reports. Medicine · 2023Article
- Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.American journal of physiology. Endocrinology and metabolism · 2023Article
- Review
- Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus.Human gene therapy · 2022Article
- Intrapleural transplantation of allogeneic pancreatic islets achieves glycemic control in a diabetic non-human primate.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Mouse models and human islet transplantation sites for intravital imaging.Frontiers in endocrinology · 2022Review
- Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles.Nano letters · 2020Article
- A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation.Advanced functional materials · 2020Article
- Article
- Article
- Engineering the vasculature for islet transplantation.Acta biomaterialia · 2019Review
- Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells.Scientific reports · 2018Article
- NLRP3 inflammasome is expressed and regulated in human islets.Cell death & disease · 2018Article
- Impact of islet size on pancreatic islet transplantation and potential interventions to improve outcome.Cell transplantation · 2015Article
- MicroRNAs in islet immunobiology and transplantation.Immunologic research · 2013Review
- Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia.Tissue engineering. Part A · 2013Article
- Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes.Diabetologia · 2013Article
- Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.Diabetes · 2013Article
- Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice.PloS one · 2013Article
- Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice.Diabetologia · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The revascularization and the structural changes resulting from interactions between the graft and the host were investigated in transplanted pancreatic islets under the kidney capsule. Islets were isolated from mice pancreata and transplanted in syngeneic diabetic animals. Graft-bearing kidneys were collected on different days post-transplant and processed for light microscopy, immunohistochemistry and transmission electron microscopy. A numerical analysis was performed in order to compare the percentage number of the different types of cells in native islets and at different time points after the transplant. Recipient animals reversed diabetes within 4 days. An intraperitoneal glucose tolerance test was performed to determine islet functionality under stressful conditions. During the initial few days post-transplant, the islets showed peculiar shapes and the graft tended to aggregate along the vessels. Starting at days 4-7 post-transplant, islets were revascularized from vessels connected to both the cortical and the capsular vascular network of the kidney. From day 7-14 post-transplant, the vessels progressively appeared more similar in features and size to those of in situ pancreatic islets. Both the percentage number of the different cell types and the distribution of Alpha, Beta and Delta cells inside the graft were significantly different as compared with intact islets, demonstrating quantitative and structural changes after the engraftment. No concomitant proliferation of Beta cells was detected using a bromodeoxyuridin staining method. Despite the fact that quick revascularization preserved a large mass of tissue, the remodelling process of the graft and the newly formed vascularization led to a different organization of the endocrine tissue as compared with intact in situ islets. This constitutes the morphological basis for alterations of the normal intercellular interactions and may explain the altered secretory cell function often observed in transplant.
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