ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2007
Symptom clusters in cancer patients with bone metastases.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Quality of life issues in patients with bone metastases: A systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.The journal of pain · 2017Pooled it
- Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Pooled it
- The Role of Inflammation in the Pain, Fatigue, and Sleep Disturbance Symptom Cluster in Advanced Cancer.Journal of pain and symptom management · 2018Trial
- Symptom Clusters in Patients With Advanced Cancer: A Prospective Longitudinal Cohort Study to Examine Their Stability and Prognostic Significance.The oncologist · 2024Article
- Validation of the Dutch version of the Edmonton Symptom Assessment System.Cancer medicine · 2020Observational
- An update in symptom clusters using the Edmonton Symptom Assessment System in a palliative radiotherapy clinic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Symptom clusters and survival in Portuguese patients with advanced cancer.Cancer medicine · 2016Article
- Effects of Dexamethasone and Placebo on Symptom Clusters in Advanced Cancer Patients: A Preliminary Report.The oncologist · 2016Article
- The psychometric properties of cancer multisymptom assessment instruments: a clinical review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Review
- Using an innovative multiple regression procedure in a cancer population (Part II): fever, depressive affect, and mobility problems clarify an influential symptom pair (pain-fatigue/weakness) and cluster (pain-fatigue/weakness-sleep problems).OncoTargets and therapy · 2015Article
- The failures and challenges of bone metastases research in radiation oncology.Journal of bone oncology · 2013Article
- Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods.World journal of oncology · 2012Article
- Cancer-related symptom clusters for symptom management in outpatients after commencing adjuvant chemotherapy, at 6 months, and 12 months.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Article
- Symptom Clusters in Cancer Patients With Bone Metastases: Subanalysis of Patients Reporting Exclusively Non-zero ESAS Scores.World journal of oncology · 2011Article
- Symptom clusters and quality of life in older adult breast cancer survivors.Oncology nursing forum · 2011Article
- Age and gender differences in symptom intensity and symptom clusters among patients with metastatic cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Article
- Multidimensional Pain Inventory-Screening Chinese version (MPI-sC): psychometric testing in terminal cancer patients in Taiwan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009Article
- Symptom clusters in patients with advanced cancers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009Article
- A review of the reliability and validity of the Edmonton Symptom Assessment System.Current oncology (Toronto, Ont.) · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to explore whether bone pain "clusters" with other symptoms in patients with bone metastases. MATERIALS AND
methodsPatients with bone metastases referred to a palliative radiotherapy clinic were asked to rate their symptom distress using the Edmonton Symptom Assessment Scale (ESAS). Analgesic consumption during the previous 24 h was captured at initial consultation. To determine interrelationships between symptoms, a principal component analysis (PCA) with "varimax rotation" was performed on the nine ESAS symptoms. This study defined a "symptom cluster" as two or more symptoms that occur together, are stable, and are relatively independent of other clusters. Patients were followed 1, 2, 4, 8, and 12 weeks post-radiation treatment by telephone. Statistical analysis was performed at each time point for both responders and nonresponders to radiation (response was defined in accordance to the International Bone Metastases Consensus Working Party).
resultsFive hundred eighteen patients with bone metastases provided complete baseline data using the ESAS. The four most prevalent symptoms were poor sense of well-being (93.5%), fatigue (92.3%), pain (84.1%), and drowsiness (81.8%). Three clusters were identified and accounted for 66% of the total variance at baseline. Cronbach's alpha coefficient demonstrated high internal reliability in the clusters, with a coefficient ranging from 0.61 to 0.81. It was observed that the clusters changed post-radiation in both responders and nonresponders and that pain clustered with different symptoms (or remained a separate symptom in responders). In nonresponders, three symptom clusters were consistently present, except in week 8.
conclusionRadiotherapy influenced the structure of symptom clusters in both responders and nonresponders. There was evidence that pain clustered out in responders of radiation to pain. It was found that pain clustered with fatigue, drowsiness, and poor sense of well-being at baseline. However, these findings must be heeded with caution, as more work is needed to clearly define symptom clusters and to understand the effects of radiation in the symptom experience of patients with bone metastases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.