ArticleDevelopment genes and evolution2007
Engrailed in cephalopods: a key gene related to the emergence of morphological novelties.
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Embryonic development of a centralised brain in coleoid cephalopods.Neural development · 2024Review
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- The Increased Expression of an Engrailed to Sustain Shell Formation in Response to Ocean Acidification.Frontiers in physiology · 2020Article
- Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates.Frontiers in physiology · 2018Review
- Possible co-option ofBiology letters · 2017Article
- Analyses of Sox-B and Sox-E Family Genes in the Cephalopod Sepia officinalis: Revealing the Conserved and the Unusual.PloS one · 2016Article
- External and internal shell formation in the ramshorn snail Marisa cornuarietis are extremes in a continuum of gradual variation in development.BMC developmental biology · 2013Article
- Possible functions of Dpp in gastropod shell formation and shell coiling.Development genes and evolution · 2011Article
- Involvement of Hox genes in shell morphogenesis in the encapsulated development of a top shell gastropod (Gibbula varia L.).Development genes and evolution · 2009Article
- Expression patterns of engrailed and dpp in the gastropod Lymnaea stagnalis.Development genes and evolution · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The engrailed gene is a transcription factor required in numerous species for major developmental steps (neurogenesis, limb development, boundary establishment), and its evolution is known to be closely related to the evolution of the metazoan body plan. Cephalopods exhibit numerous morphological peculiarities among molluscs, such as a direct development, a complex sensory and nervous system (eyes, brain, giant axons), a reduced shell, a funnel, and a brachial crown. We assessed a potential recruitment of engrailed in the development of these derived traits and examined the expression pattern of engrailed during the organogenesis of the cuttlefish Sepia officinalis, by immunostaining. Engrailed was detected at the margin of the prospective internal shell, which is consistent with studies on molluscs having an external shell and confirms a conserved role of engrailed in delimitating the molluscan shell compartment. Interestingly, unexpected patterns were early detected in the emerging arms, funnel and optic vesicles and latter in tentacles and eye lids. We also identified an engrailed cognate in the squid Loligo, which provides new evidence that engrailed in molluscs is not restricted to a 'shell function' and has been recruited in the mollusc lineage for the emergence of morphological novelties in cephalopods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.