ArticleHepatology (Baltimore, Md.)2007
Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice.
Article in Hepatology (Baltimore, Md.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- Bempedoic acid within the phase ternary diagram governing biliary cholesterol solubilization and gallstone risk.Journal of lipid research · 2026Review
- Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study.Scientific reports · 2023Article
- Differential Effects ofGenes · 2023Article
- Sitosterolemia: Twenty Years of Discovery of the Function ofInternational journal of molecular sciences · 2021Review
- Case Report: Next Generation Sequencing in Clinical Practice-A Real Tool for Ending the Protracted Diagnostic Odyssey.Frontiers in cardiovascular medicine · 2021Article
- Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice.Gastroenterology research and practice · 2020Article
- Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5/G8 in Health and Disease.Advances in experimental medicine and biology · 2020Review
- Slc12a8 is a nicotinamide mononucleotide transporter.Nature metabolism · 2019Article
- ABCG5 and ABCG8: more than a defense against xenosterols.Journal of lipid research · 2018Review
- Mouse models of gallstone disease.Current opinion in gastroenterology · 2018Review
- New insights into the role ofLiver research (Beijing, China) · 2017Article
- Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice.Hepatology (Baltimore, Md.) · 2016Article
- ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph.Lipids · 2015Article
- Relative roles of ABCG5/ABCG8 in liver and intestine.Journal of lipid research · 2015Article
- Hepatic or intestinal ABCG5 and ABCG8 are sufficient to block the development of sitosterolemia.Journal of lipid research · 2015Article
- New insights into the molecular mechanism of intestinal fatty acid absorption.European journal of clinical investigation · 2013Review
- Evaluation of the contribution of the ATP binding cassette transporter, P-glycoprotein, to in vivo cholesterol homeostasis.Molecular pharmaceutics · 2013Article
- Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease.BMC gastroenterology · 2013Article
- Investigating Sitosterolemia to Understand Lipid Physiology.Clinical lipidology · 2013Article
- ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.Journal of lipid research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
unlabelledSitosterolemia is caused by mutations in either ABCG5 or ABCG8, but simultaneous mutations of these genes have never been observed. To explore whether ABCG8, the sterol efflux (hemi-)transporter, plays a major role in determining intestinal absorption efficiency and hepatic secretion rates of cholesterol and sitostanol, we performed direct measurements of the absorption and lymphatic transport of these sterols in mice with chronic biliary and lymphatic fistulae, as well as the transport rates of radiolabeled cholesterol and sitostanol from plasma high-density lipoprotein (HDL) into bile in male Abcg8(-/-) and wild-type mice. We observed that the absorption and lymphatic transport rates of radiolabeled cholesterol and sitostanol were increased by approximately 40% and approximately 500%, respectively, in Abcg8(-/-) mice in the setting of constant intraduodenal infusion of micellar taurocholate and lecithin. Both strains displayed identical intestinal Npc1l1 expression levels and small intestinal transit rates. After 45 minutes of intraduodenal infusion, acute intestinal uptake rates of trace [(14)C]cholesterol and [(3)H]sitostanol were essentially similar in both groups of mice with intact biliary secretion. Furthermore, in wild-type mice, mass transport rate of [(3)H]sitostanol from plasma HDL into bile was significantly faster than that of [(14)C]cholesterol; however, no [(3)H]sitostanol and only traces of [(14)C]cholesterol were detected in bile of Abcg8(-/-) mice.
conclusionDeletion of the Abcg8 gene alone significantly increases the mass of intestinal cholesterol and sitostanol absorption and reduces but does not eliminate hepatic secretion of cholesterol. Moreover, the mutation has no influence on acute uptake of cholesterol and sitostanol by the enterocyte nor small intestinal transit time.
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