ArticleArthritis and rheumatism2007
Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.
Article in Arthritis and rheumatism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Kidney immunology from pathophysiology to clinical translation.Nature reviews. Immunology · 2025Review
- Unconventional T cells and kidney disease.Nature reviews. Nephrology · 2021Review
- B cells interactions in lipid immune responses: implications in atherosclerotic disease.Lipids in health and disease · 2017Review
- Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis.Journal of immunology research · 2016Review
- Remission of systemic lupus erythematosus disease activity with regulatory cytokine interleukin (IL)-35 in Murphy Roths Large (MRL)/lpr mice.Clinical and experimental immunology · 2015Article
- Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.European journal of immunology · 2015Article
- The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8(+) T Cell Generation.Frontiers in immunology · 2015Review
- Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.Journal of autoimmunity · 2014Article
- O death where is thy sting? Immunologic tolerance to apoptotic self.Cellular and molecular life sciences : CMLS · 2013Review
- Intrinsic hyporesponsiveness of invariant natural killer T cells precedes the onset of lupus.Clinical and experimental immunology · 2013Article
- Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus.Arthritis research & therapy · 2013Article
- Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?Clinical and experimental immunology · 2013Review
- Dysfunction of natural killer T cells in patients with active Mycobacterium tuberculosis infection.Infection and immunity · 2012Article
- Article
- Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus.Journal of clinical immunology · 2012Article
- Modulatory function of invariant natural killer T cells in systemic lupus erythematosus.Clinical & developmental immunology · 2012Review
- MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The split personality of NKT cells in malignancy, autoimmune and allergic disorders.Immunotherapy · 2011Review
- Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis.Hepatology (Baltimore, Md.) · 2011Article
- Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCD1d-reactive invariant natural killer T (iNKT) cells secrete multiple cytokines upon T cell receptor (TCR) engagement and modulate many immune-mediated conditions. The purpose of this study was to examine the role of these cells in the development of autoimmune disease in genetically lupus-prone (NZBxNZW)F1 (BWF1) mice.
methodsThe CD1d1-null genotype was crossed onto the NZB and NZW backgrounds to establish CD1d1-knockout (CD1d0) BWF1 mice. CD1d0 mice and their wild-type littermates were monitored for the development of nephritis and assessed for cytokine responses to CD1d-restricted glycolipid alpha-galactosylceramide (alphaGalCer), anti-CD3 antibody, and concanavalin A (Con A). Thymus and spleen cells were stained with CD1d tetramers that had been loaded with alphaGalCer or its analog PBS-57 to detect iNKT cells, and the cells were compared between BWF1 mice and class II major histocompatibility complex-matched nonautoimmune strains, including BALB/c, (BALB/cxNZW)F1 (CWF1), and NZW.
resultsCD1d0 BWF1 mice had more severe nephritis than did their wild-type littermates. Although iNKT cells and iNKT cell responses were absent in CD1d0 BWF1 mice, the CD1d0 mice continued to have significant numbers of interferon-gamma-producing NKT-like (CD1d-independent TCRbeta+,NK1.1+ and/or DX5+) cells. CD1d deficiency also influenced cytokine responses by conventional T cells: upon in vitro stimulation of splenocytes with Con A or anti-CD3, type 2 cytokine levels were reduced, whereas type 1 cytokine levels were increased or unchanged in CD1d0 mice as compared with their wild-type littermates. Additionally, numbers of thymic iNKT cells were lower in young wild-type BWF1 mice than in nonautoimmune strains.
conclusionGermline deletion of CD1d exacerbates lupus in BWF1 mice. This finding, together with reduced thymic iNKT cells in young BWF1 mice as compared with nonautoimmune strains, implies a regulatory role of CD1d and iNKT cells during the development of lupus.
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