ArticleEuropean journal of immunology2007
CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions.
Article in European journal of immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- MHC-related protein 1-restricted recognition of cancer via a semi-invariant TCR-α chain.The Journal of clinical investigation · 2025Article
- HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes.The Journal of clinical investigation · 2024Article
- Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes.Cancer immunology research · 2023Article
- CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope.Frontiers in immunology · 2020Article
- Article
- Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.The Journal of biological chemistry · 2017Article
- More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.Immunology · 2015Review
- Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Clinical and experimental immunology · 2014Article
- The molecular determinants of CD8 co-receptor function.Immunology · 2012Review
- IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation.Protein & cell · 2010Article
- Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.The Journal of biological chemistry · 2009Article
- The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Review
- Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.Journal of virology · 2008Article
- Class II major histocompatibility complex tetramer staining: progress, problems, and prospects.Immunology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cytotoxic T lymphocytes (CTL) are equipped with a range of effector functions that contribute both to the control of intracellular pathogens and dysregulated cellular proliferation and to the development of certain immunopathologies such as autoimmune disease. Qualitative analyses of various CTL responses have revealed substantial heterogeneity in the diversity of functions that are mobilized in response to antigen. Here, we studied the influence of the CD8 co-receptor, which is known to enhance antigen recognition by CTL, on the secretion of eight different cytokines and chemokines by human CTL clones using flow cytometric bead array. Our results show that abrogation of MHC class I/CD8 interactions exerts a differential influence on the distinct individual effector functions that are elicited in response to agonist ligands. The magnitude of this co-receptor blockade inhibitory effect was clearly related to the hierarchy of cytokine secretion in terms of activation threshold because those functions requiring the highest amounts of antigen were most affected. Thus, modulation of CD8 activity can effectively tune not only the sensitivity but also the qualitative profile of CTL responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.