ArticleDigestive diseases and sciences2007
Diabetic rats supplemented with L-glutamine: a study of immunoreactive myosin-V myenteric neurons and the proximal colonic mucosa.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Cancer-induced morphological changes in enteric glial cells in the jejunum of Walker-256 tumor-bearing rats.Acta histochemica · 2024Article
- Antioxidant Effects of the Quercetin in the Jejunal Myenteric Innervation of Diabetic Rats.Frontiers in medicine · 2017Article
- Article
- Is L-glutathione more effective than L-glutamine in preventing enteric diabetic neuropathy?Digestive diseases and sciences · 2014Article
- Neuroprotective effect of quercetin on the duodenum enteric nervous system of streptozotocin-induced diabetic rats.Digestive diseases and sciences · 2012Article
- Diabetes-related alterations in the enteric nervous system and its microenvironment.World journal of diabetes · 2012Article
- L-glutamine supplementation prevents myenteric neuron loss and has gliatrophic effects in the ileum of diabetic rats.Digestive diseases and sciences · 2011Article
- Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats.World journal of gastroenterology · 2011Article
- Vitamin E (alpha-tocopherol) supplementation in diabetic rats: effects on the proximal colon.BMC gastroenterology · 2009Article
- Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum.Journal of molecular histology · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
We studied the neuronal density and size of myenteric neurons and the epithelial cell proliferation and crypt depth of the proximal colon in diabetic Wistar rats after supplementing them with L-glutamine (1%). The animals were divided into five groups: untreated normoglycemic (UN), L-glutamine-treated normoglycemic (NG), untreated diabetic (UD), and L-glutamine-treated diabetics 4 days (DG4) and 45 days (DG45) days after the onset of diabetes. We observed a reduction of 52.7% and 50.44% in the neuronal density of the proximal colon of the UD group compared to the UN and NG groups, respectively (P<0.05). The neuronal density found for the DG4 (32.8%) and DG45 (28.6%) groups was higher than that of the UD group (P>0.05). There were no significant differences (P>0.05) when the data relative to the area of the myenteric neuron cell bodies, metaphasic index, and crypt depth in the proximal colon were compared among experimental groups.
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