Evidence map›Paper›PMID 17393201›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2007

Use of pyrosequencing to identify point mutations in domain V of 23S rRNA genes of linezolid-resistant Staphylococcus aureus and Staphylococcus epidermidis.

W Zhu, F C Tenover, J Limor, D Lonsway, D Prince, W M Dunne, J B Patel

Abstract read
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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  4. Article
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  6. Article
  7. The emerging problem of linezolid-resistant Staphylococcus.The Journal of antimicrobial chemotherapy · 2013
    Review
  8. Article
  9. Article
  10. Endemic linezolid-resistant Staphylococcus epidermidis in a critical care unit.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

W ZhuDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, MS-G08, Atlanta, GA 30333, USA.
F C Tenover
J Limor
D Lonsway
D Prince
W M Dunne
J B Patel
Centers for Disease Control and Prevention · USPiedmont Atlanta Hospital · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pyrosequencing assay was used for the rapid characterization of linezolid-resistant isolates of Staphylococcus aureus and Staphylococcus epidermidis. The assay identified base substitutions in copies of the 23S rRNA gene and determined the percentage of alleles with the mutation. Modifications of the assay were necessary to identify all mutations in the 23S rRNA genes of S. epidermidis that were associated with linezolid resistance. A C2534T mutation was identified in S. epidermidis that was not previously reported in a linezolid-resistant isolate.

Indexed as

Point MutationAcetamidesAnti-Infective AgentsBase SequenceDNA PrimersDrug Resistance, BacterialHumansLinezolidMicrobial Sensitivity TestsMolecular Sequence DataOxazolidinonesPolymorphism, Single NucleotideRNA, Ribosomal, 23SStaphylococcus aureusStaphylococcus epidermidisAcetamidesAnti-Infective AgentsDNA PrimersLinezolidOxazolidinonesRNA, Ribosomal, 23S

Identifiers

PMID17393201
OpenAlexW2012069164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.