Evidence map›Paper›PMID 17392816›Full record

ReviewLeukemia2007

Working hypothesis to redefine endothelial progenitor cells.

D N Prater, J Case, D A Ingram, M C Yoder

Abstract readReview
PubMed Publisher
In one paragraph

Review in Leukemia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Endothelial Progenitor Cells in Life, Pregnancy and Disease.Expert reviews in molecular medicine · 2025
    Review
  2. Article
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  5. Review
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  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

D N PraterDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
J Case
D A Ingram
M C Yoder

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
Transgenic CoreP50NS052606 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI CLAPP, DAVID W · 2005 to 2014
$12.6M
Transplant and Imaging of Human Stem and Progenitor Cells in Nonhuman PrimatesP50HL085036 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI ROCKE, DAVID M. · 2005 to 2008
$5.8M
GDM Effect on Maternal/Neonatal Endothelial ProgenitorsR21HL088885 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI HANELINE, LAURA S · 2006 to 2007
$403k
NCI NIH HHS P30 CA82709NHLBI NIH HHS P01 HL085036NHLBI NIH HHS R21 HL088885NINDS NIH HHS P50 NS052606
6 · The paper itself

Abstract

Since 1997, postnatal vasculogenesis has been purported to be an important mechanism for neoangiogenesis via bone marrow (BM)-derived circulating endothelial progenitor cells (EPCs). Based on this paradigm, EPCs have been extensively studied as biomarkers to assess severity of cardiovascular disease and as a cell-based therapy for several human cardiovascular disorders. In the majority of studies to date, EPCs were identified and enumerated by two primary methodologies; EPCs were obtained and quantified following in vitro cell culture, or EPCs were identified and enumerated by flow cytometry. Both methods have proven controversial. This review will attempt to outline the definition of EPCs from some of the most widely cited published reports in an effort to provide a framework for understanding subsequent studies in this rapidly evolving field. We will focus this review on studies that used cell culture techniques to define EPCs.

Indexed as

AnimalsCell CountCell Culture TechniquesEndothelial CellsHumansImmunophenotypingStem CellsTerminology as Topic

Identifiers

PMID17392816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.