ArticleMediators of inflammation2006
Tumor necrosis factor-alpha in temporomandibular joint synovial fluid predicts treatment effects on pain by intra-articular glucocorticoid treatment.
Article in Mediators of inflammation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Application of fully digital occlusal splints in painful temporomandibular disorders: a randomized controlled clinical study.Head & face medicine · 2026Trial
- Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study.Medicina (Kaunas, Lithuania) · 2020Trial
- TMJ hyperextension is associated with sustained nociception and dysfunction of pain modulation pathways in female rats.Cranio : the journal of craniomandibular practice · 2026Article
- Whole Transcriptomic Analysis Identifies Candidate Biomarkers from Saliva of Temporomandibular Joint Osteoarthritis Patients.International journal of molecular sciences · 2026Article
- The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.Dentistry journal · 2024Review
- Lycopene as a Potential Anti-inflammatory Therapeutic Agent for Temporomandibular Joint Disorders: A Narrative Review.Journal of pharmacy & bioallied sciences · 2024Review
- Efficacy of IFN-γ-Primed Umbilical Cord-Derived Mesenchymal Stem Cells on Temporomandibular Joint Osteoarthritis.Tissue engineering and regenerative medicine · 2024Article
- Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis.Journal of dental sciences · 2023Review
- Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation.Journal of oral rehabilitation · 2022Article
- C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats.Journal of immunology research · 2022Article
- Corticosteroid injections in the temporomandibular joint temporarily alleviate pain and improve function in rheumatoid arthritis.Clinical rheumatology · 2021Article
- A comprehensive review on biomarkers associated with painful temporomandibular disorders.International journal of oral science · 2021Review
- Proteomic Expression Profile in Human Temporomandibular Joint Dysfunction.Diagnostics (Basel, Switzerland) · 2021Article
- Biomarkers for Temporomandibular Disorders: Current Status and Future Directions.Diagnostics (Basel, Switzerland) · 2020Review
- Biomarkers in Temporomandibular Disorder and Trigeminal Neuralgia: A Conceptual Framework for Understanding Chronic Pain.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Tumor necrosis factor-Alpha stimulates cytokine expression and transient sensitization of trigeminal nociceptive neurons.Archives of oral biology · 2017Article
- Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements.Medicina oral, patologia oral y cirugia bucal · 2016Article
- Psychoeducation program on strategies for coping with stress in patients with temporomandibular joint dysfunction.BioMed research international · 2014Article
- Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders.Journal of oral rehabilitation · 2014Review
- Controlled release of anti-inflammatory siRNA from biodegradable polymeric microparticles intended for intra-articular delivery to the temporomandibular joint.Pharmaceutical research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the influence of tumor necrosis factor-alpha (TNF-alpha) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pretreatment level of TNF-alpha in the synovial fluid was associated with a decrease of TNF-alpha and elimination of pain upon maximal mouth opening. Elimination of this TMJ pain was accordingly associated with decrease in synovial fluid level of TNF-alpha. There was also a significant decrease of C-reactive protein and TMJ resting pain after treatment. In conclusion, this study indicates that presence of TNF-alpha in the synovial fluid predicts a treatment effect of intra-articular injection of glucocorticoid on TMJ movement pain in patients with chronic TMJ inflammatory disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.