ArticleMediators of inflammation2006
Adjusting effects of baicalin for nuclear factor-kappaB and tumor necrosis factor-alpha on rats with caerulein-induced acute pancreatitis.
Article in Mediators of inflammation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Review
- Beneficial Effect of Kidney Bean Resistant Starch on Hyperlipidemia-Induced Acute Pancreatitis and Related Intestinal Barrier Damage in Rats.Molecules (Basel, Switzerland) · 2022Article
- Rhein Protects Against Severe Acute PancreatitisFrontiers in pharmacology · 2022Article
- Dai-Huang-Fu-Zi-Tang alleviates pulmonary and intestinal injury with severe acute pancreatitis via regulating aquaporins in rats.BMC complementary and alternative medicine · 2017Article
- Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms.Frontiers in pharmacology · 2017Review
- Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1.Experimental and therapeutic medicine · 2014Article
- Modular analysis of bioinformatics demonstrates a critical role for NF-κB in macrophage activation.Inflammation · 2014Article
- UP446, analgesic and anti-inflammatory botanical composition.Pharmacognosy research · 2013Article
- Study of dexamethasone, baicalin and octreotide on brain injury of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis.Journal of Zhejiang University. Science. B · 2011Article
- Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.British journal of pharmacology · 2010Article
- NSAIDs and Acute Pancreatitis: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Baicalin attenuates air embolism-induced acute lung injury in rat isolated lungs.British journal of pharmacology · 2009Article
- Histomorphological and Immunohistochemical Study of Dacomitinib-Induced Ileal Mucositis in Rats with the Possible Protection by Baicalin.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forty Wistar rats were divided into 5 groups, including the control group, the acute pancreatitis group (AP group, induced by intraperitoneal injections of caerulein), and the AP group treated with baicalin, the AP group treated with LPS, and the AP group treated with LPS and baicalin. Pathological damage of pancreatic tissue was scored with hematoxylin and eosin (HE) staining. The mRNA expression of TNF-alpha was measured with semiquantitative RT-PCR, and activation of NF-kappaB was detected with flow cytometry assay. It was shown in the results that the expression of TNF-alpha mRNA, activation of NF-kappaB, and pathological score of AP group were all obviously higher than those of control group (P < .01). In AP group treated with LPS, further rise of these values were observed (P < .01). In the AP group treated with baicalin, activation of NF-kappaB decreased (P < .05), and expression of TNF-alpha mRNA also obviously decreased (P < .01), while pancreatic pathological damage was alleviated at the same time (P < .01); similar results were observed in AP group treated with LPS and baicalin (P < .01), which indicated that baicalin might be applied to inhibit NF-kappaB activating and TNF-alpha expressing so as to treat AP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.