ArticleMolecular biology of the cell2007
Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization.PLoS genetics · 2020Article
- The half-bridge component Kar1 promotes centrosome separation and duplication during budding yeast meiosis.Molecular biology of the cell · 2018Article
- Cleavage of the SUN-domain protein Mps3 at its N-terminus regulates centrosome disjunction in budding yeast meiosis.PLoS genetics · 2017Article
- Duplication of the Yeast Spindle Pole Body Once per Cell Cycle.Molecular and cellular biology · 2016Review
- Article
- Article
- Ndj1, a telomere-associated protein, regulates centrosome separation in budding yeast meiosis.The Journal of cell biology · 2015Article
- Licensing of yeast centrosome duplication requires phosphoregulation of sfi1.PLoS genetics · 2014Article
- Regulation of spindle pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast.Molecular biology of the cell · 2014Article
- Lessons from yeast: the spindle pole body and the centrosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Article
- Mitotic spindle form and function.Genetics · 2012Article
- Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin.Frontiers in immunology · 2012Article
- A genome-wide association study for diabetic nephropathy genes in African Americans.Kidney international · 2011Article
- Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes.The Journal of biological chemistry · 2011Article
- Rising cyclin-CDK levels order cell cycle events.PloS one · 2011Article
- Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.Nature cell biology · 2010Article
- Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.Molecular biology of the cell · 2008Article
- An Sfi1p-like centrin-binding protein mediates centrin-based Ca2+ -dependent contractility in Paramecium tetraurelia.Eukaryotic cell · 2007Article
- Nuclear envelope insertion of spindle pole bodies and nuclear pore complexes.Nucleus (Austin, Tex.)Review
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Authors and funding
5 authors.
Funding
Abstract
A variety of spindle and kinetochore defects have been shown to induce a mitotic delay through activation of the spindle checkpoint. With the aim of identifying novel mitotic defects we carried out a mad1 synthetic lethal screen in budding yeast. In this screen, four novel alleles of sfi1 were isolated. SFI1 is an essential gene, previously identified through its interaction with centrin/CDC31 and shown to be required for spindle pole body (SPB) duplication. The new mutations were all found in the C-terminal domain of Sfi1p, which has no known function, but it is well conserved among budding yeasts. Analysis of the novel sfi1 mutants, through a combination of light and electron microscopy, revealed duplicated SPBs <0.3 microm apart. Importantly, these SPBs have completed duplication, but they are not separated, suggesting a possible defect in splitting of the bridge. We discuss possible roles for Sfi1p in this step in bipolar spindle assembly.
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