ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
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- Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane.Experimental & molecular medicine · 2018Article
- Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms.Acta neuropathologica · 2017Review
- Oligodendroglial membrane dynamics in relation to myelin biogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.Molecular and cellular biology · 2015Article
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- Axon-glia interaction and membrane traffic in myelin formation.Frontiers in cellular neuroscience · 2014Review
- Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.Developmental biology · 2013Article
- CD82 blocks cMet activation and overcomes hepatocyte growth factor effects on oligodendrocyte precursor differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Myosin II is a negative regulator of oligodendrocyte morphological differentiation.Journal of neuroscience research · 2012Article
- Polarization and myelination in myelinating glia.ISRN neurology · 2012Article
- MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination.Journal of cell science · 2011Article
- RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury.Experimental neurology · 2011Article
- From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation of oligodendrocytes is associated with dramatic changes in plasma membrane structure, culminating in the formation of myelin membrane sheaths. Previous results have provided evidence that regulation of endocytosis may represent a mechanism to control myelin membrane growth. Immature oligodendrocytes have a high rate of clathrin-independent endocytosis for the transport of membrane to late endosomes/lysosomes (LE/Ls). After maturation and receiving signals from neurons, endocytosis is reduced and transport of membrane from LE/Ls to the plasma membrane is triggered. Here, we show that changes in Rho GTPase activity are responsible for switching between these two modes of membrane transport. Strikingly, Rho inactivation did not only reduce the transport of cargo to LE/L but also increased the dynamics of LE/L vesicles. Furthermore, we provide evidence that Rho inactivation results in the condensation of the plasma membrane in a polarized manner. In summary, our data reveal a novel role of Rho: to regulate the flow of membrane and to promote changes in cell surface structure and polarity in oligodendroglial cells. We suggest that Rho inactivation is required to trigger plasma membrane specialization in oligodendrocytes.
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