ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 106 citations in OpenAlex.
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- A brain-gut excitatory peptide/CCHamide homolog regulates satiation and motivational state transitions in the Aplysia feeding circuit.The Journal of biological chemistry · 2026Article
- Identification of a G Protein-Coupled Receptor for Buccalin-Type Peptides in the MolluskACS omega · 2025Article
- Article
- Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.Cell reports · 2025Article
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- Convergent effects of peptides on the initiation of feeding motor programs in the molluskJournal of neurophysiology · 2025Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.Scientific reports · 2023Article
- Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles.The Journal of biological chemistry · 2022Article
- Convergent effects of neuropeptides on the feeding central pattern generator ofJournal of neurophysiology · 2022Article
- In the sea slugFrontiers in physiology · 2022Article
- Methodological considerations in studying digestive system physiology in octopus: limitations, lacunae and lessons learnt.Frontiers in physiology · 2022Review
- NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai.Scientific reports · 2021Article
- An Anticipatory Circuit Modification That Modifies Subsequent Task Switching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity.eLife · 2020Article
- Feeding, hunger, satiety and serotonin in invertebrates.Proceedings. Biological sciences · 2020Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
A shift in motivational state often produces behavioral change, but the underlying mechanisms are poorly understood. In the marine mollusc, Aplysia californica, feeding-induced transition from a hunger to satiation state leads to a slowdown and an eventual termination of feeding. Because the multifunctional feeding network generates both ingestion and the competing response, egestion, it is possible that the transition from a hunger to a satiety state is associated with network reconfiguration that results in production of fewer ingestive and more egestive responses. Chronic electrophysiological recordings in free-feeding Aplysia showed that as the meal progressed, food elicited fewer ingestive responses and simultaneously increased the number of egestive responses. Injections of Aplysia neuropeptide Y (apNPY) reduced food intake and slowed down the rate of ingestion. apNPY was localized to buccal-ganglion afferents originating in the gut-innervating esophageal nerve (EN), a nerve involved both in satiation and in the generation of egestive programs. During EN stimulation, apNPY was released in the feeding circuit. Importantly, stimulation of the cerebral-buccal interneuron-2, a command-like interneuron that is activated by food and normally elicits ingestive responses, elicited egestive responses in the presence of apNPY. This was accompanied by increased activity of the egestion-promoting interneuron B20 and decreased activity in the ingestion-promoting interneuron B40. Thus, apNPYergic reconfiguration of the feeding central pattern generator plays a role in the gradual transition from hunger to satiety states. More generally, changes in the motivational states may involve not only simple network inhibition but may also require network reconfiguration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.