ReviewJournal of virology2007
Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo.
Review in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Structure-specific nucleases in genome dynamics and strategies for targeting cancers.Journal of molecular cell biology · 2024Review
- Factors that mold the nuclear landscape of HIV-1 integration.Nucleic acids research · 2021Review
- Article
- Studies of retroviral infection in humanized mice.Virology · 2015Review
- Article
- Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.Viruses · 2013Review
- Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle.Retrovirology · 2013Article
- The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis.Virology · 2013Review
- Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.The Journal of biological chemistry · 2012Review
- The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.International journal of biochemistry and molecular biology · 2012Article
- Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.Retrovirology · 2011Article
- HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes.Virology · 2011Article
- Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages.Antimicrobial agents and chemotherapy · 2011Article
- The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.Journal of virology · 2010Article
- Article
- Retroviral reverse transcriptases.Cellular and molecular life sciences : CMLS · 2010Review
- Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.Journal of virology · 2010Article
- Establishment and maintenance of HIV latency: model systems and opportunities for intervention.Future virology · 2010Article
- Analysis of the viral elements required in the nuclear import of HIV-1 DNA.Journal of virology · 2010Article
- HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.Retrovirology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The central DNA flap is an important component of lentiviral vectors, but its significance in the context of wild-type human immunodeficiency virus (HIV) is currently unclear. To address this issue, we have compared the in vitro infection kinetics of NL4-3 with those of a flap-deficient mutant and evaluated the in vivo growth characteristics of these viruses by using the SCID-hu mouse model of HIV infection. Flap-deficient virus was only modestly attenuated in vitro, as assessed by single-round and spreading infection assays, and exhibited levels of replication and pathogenesis close to those of the wild-type in vivo. Hence, an intact central flap is not essential for HIV replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.