ArticleJournal of virology2007
Enteric ganglionitis in rhesus macaques infected with simian immunodeficiency virus.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The enteric nervous system.Physiological reviews · 2023Review
- Review
- Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.PloS one · 2022Article
- Research Relevant Conditions and Pathology in Nonhuman Primates.ILAR journal · 2020Review
- Intraganglionic macrophages: a new population of cells in the enteric ganglia.Journal of anatomy · 2018Article
- Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques.Gene therapy · 2017Article
- Effects of HIV-1 Tat on enteric neuropathogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neurochemical phenotypes of myenteric neurons in the rhesus monkey.The Journal of comparative neurology · 2011Article
- Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- The gastrointestinal tract and AIDS pathogenesis.Gastroenterology · 2009Review
- Repeated occurrence of jejuno-jejunal intussusception in a calf.The Canadian veterinary journal = La revue veterinaire canadienne · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Gastrointestinal (GI) disease is a debilitating feature of human immunodeficiency virus (HIV) infection that can occur in the absence of histopathological abnormalities or identifiable enteropathogens. However, the mechanisms of GI dysfunction are poorly understood. The present study was undertaken to characterize changes in resident and inflammatory cells in the enteric nervous system (ENS) of macaques during the acute stage of simian immunodeficiency virus (SIV) infection to gain insight into potential pathogenic mechanisms of GI disease. Ganglia from duodenum, ileum, and colon were examined in healthy and acutely infected macaques by using a combination of routine histology, double-label immunofluorescence and in situ hybridization. Evaluation of tissues from infected macaques showed progressive infiltration of myenteric ganglia by CD3+ T cells and IBA1+ macrophages beginning as early as 8 days postinfection. Quantitative image analysis revealed that the severity of myenteric ganglionitis increased with time after SIV infection and, in general, was more severe in ganglia from the small intestine than in ganglia from the colon. Despite an abundance of inflammatory cells in myenteric ganglia during acute infection, the ENS was not a target for virus infection. This study provides evidence that the ENS may be playing a role in the pathogenesis of GI disease and enteropathy in HIV-infected people.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.