ArticleNucleic acids research2007
Ribosomal protein S1 influences trans-translation in vitro and in vivo.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere.The ISME journal · 2026Article
- Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.International journal of molecular sciences · 2024Review
- Structural insights into the binding of bS1 to the ribosome.Nucleic acids research · 2023Article
- Yet Another Similarity between Mitochondrial and Bacterial Ribosomal Small Subunit Biogenesis Obtained by Structural Characterization of RbfA fromInternational journal of molecular sciences · 2023Article
- Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.Nature communications · 2021Article
- Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure.Nucleic acids research · 2020Article
- Solution structure and backbone dynamics for S1 domain of ribosomal protein S1 from Mycobacterium tuberculosis.European biophysics journal : EBJ · 2019Article
- Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti-tuberculosis activity.Clinical and translational medicine · 2018Review
- Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.Nature microbiology · 2018Article
- Structural dynamics of protein S1 on the 70S ribosome visualized by ensemble cryo-EM.Methods (San Diego, Calif.) · 2018Article
- An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System.Applied and environmental microbiology · 2018Article
- A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.BMC genomics · 2017Article
- Antibiotic resistance mechanisms in M. tuberculosis: an update.Archives of toxicology · 2016Review
- Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.BMC molecular biology · 2014Article
- Mechanism of trans-translation revealed by in vitro studies.Frontiers in microbiology · 2014Review
- Molecular biology of drug resistance in Mycobacterium tuberculosis.Current topics in microbiology and immunology · 2013Review
- Ribosomal protein S1 unwinds double-stranded RNA in multiple steps.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Direct interaction of the N-terminal domain of ribosomal protein S1 with protein S2 in Escherichia coli.PloS one · 2012Article
- Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.Science (New York, N.Y.) · 2011Article
- tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation.Journal of nucleic acids · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When the bacterial ribosome stalls on a truncated mRNA, transfer-messenger RNA (tmRNA) acts initially as a transfer RNA (tRNA) and then as a messenger RNA (mRNA) to rescue the ribosome and add a peptide tag to the nascent polypeptide that targets it for degradation. Ribosomal protein S1 binds tmRNA but its functional role in this process has remained elusive. In this report, we demonstrate that, in vitro, S1 is dispensable for the tRNA-like role of tmRNA but is essential for its mRNA function. Increasing or decreasing the amount of protein S1 in vivo reduces the overall amount of trans-translated proteins. Also, a truncated S1 protein impaired for ribosome binding can still trigger protein tagging, suggesting that S1 interacts with tmRNA outside the ribosome to keep it in an active state. Overall, these results demonstrate that S1 has a role in tmRNA-mediated tagging that is distinct from its role during canonical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.