ArticleThe American journal of pathology2007
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Irradiation with a mixed heavy ion beam induces ovarian follicle loss and dose-dependent mixed ovarian tumor development.Biology of reproduction · 2026Article
- Sex Differences in Embryonic Gonad Transcriptomes and Benzo[a]pyrene Metabolite Levels After Transplacental Exposure.Endocrinology · 2022Article
- Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.Nature aging · 2021Article
- COX-2 Silencing in Canine Malignant Melanoma Inhibits Malignant Behaviour.Frontiers in veterinary science · 2021Article
- Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors.Radiation research · 2018Article
- Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.Molecular and cellular biology · 2016Article
- Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.Oncotarget · 2016Article
- Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.Neoplasia (New York, N.Y.) · 2015Article
- Development of a mouse model of menopausal ovarian cancer.Frontiers in oncology · 2014Review
- Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.Biology of reproduction · 2013Article
- Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.Cancer research · 2013Article
- White spotting variant mouse as an experimental model for ovarian aging and menopausal biology.Menopause (New York, N.Y.) · 2012Article
- Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer.Chinese journal of cancer · 2011Review
- Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models.Gynecologic oncology · 2010Article
- Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion.The Lancet. Oncology · 2008Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Menopausal ovaries undergo morphological changes, known as ovarian aging, which are implicated in the high incidence of ovarian cancer occurring during the perimenopausal and immediate postmenopausal periods. The germ cell-deficient Wv mice recapitulate these postmenopausal alterations in ovarian morphology and develop tubular adenomas. We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory increase in ovarian cyclooxygenase 1 expression and prostaglandin E(2) synthesis. Cyclooxygenase inhibitors also reduced the tumor phenotype in a preliminary study. These findings suggest that increased cyclooxygenase activity contributes to the preneoplastic morphological changes of the ovarian surface epithelium, which can be reversed by a reduction of gene dosage achieved by either genetic or pharmacological approaches.
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