ArticleThe American journal of pathology2007
G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 105 citations in OpenAlex.
- Pathophysiologic response to severe burn injury.Annals of surgery · 2008Trial
- G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis.Journal of orthopaedic translation · 2024Article
- The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease.Frontiers in cardiovascular medicine · 2023Review
- Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease.Endocrine reviews · 2022Review
- G protein estrogen receptor as a potential therapeutic target in Raynaud's phenomenon.Frontiers in pharmacology · 2022Article
- Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension.Frontiers in cardiovascular medicine · 2021Review
- GPER1 and microRNA: Two Players in Breast Cancer Progression.International journal of molecular sciences · 2020Review
- Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome?Journal of clinical medicine · 2020Review
- Article
- GPER-induced signaling is essential for the survival of breast cancer stem cells.International journal of cancer · 2020Article
- Does GPER Really Function as a G Protein-Coupled Estrogen ReceptorFrontiers in endocrinology · 2020Review
- Individualized medicine: Sex, hormones, genetics, and adverse drug reactions.Pharmacology research & perspectives · 2019Review
- Article
- Gender differences in trauma, shock and sepsis.Military Medical Research · 2018Review
- Article
- Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males.Scientific reports · 2017Article
- The influence of sex steroid hormones on the response to trauma and burn injury.Burns & trauma · 2017Review
- The presence of the ovary prevents hepatic mitochondrial oxidative stress in young and aged female mice through glutathione peroxidase 1.Experimental gerontology · 2016Article
- A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release.The Journal of cell biology · 2015Article
- International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.Pharmacological reviews · 2015Review
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7 authors at 1 institution in 1 country.
Funding
Abstract
Although nongenomic effects of 17beta-estradiol (E2) are mediated via the estrogen receptor alpha (ER-alpha), the existence of another novel ER, G protein-coupled receptor 30 (GPR30), has been suggested as a candidate for triggering a broad range of E2-mediated signaling. GPR30 also acts independently of the ER to promote activation of the protein kinase A (PKA) pathway, which protects cells from apoptosis through Bcl-2. In this study, we examined whether the salutary effects of E2 in attenuating hepatic injury after trauma-hemorrhage are mediated via GPR30- or ER-alpha-regulated activation of PKA-dependent signaling. At 2 hours after trauma-hemorrhage, administration of E2-conjugated to bovine serum albumin (E2-BSA, membrane impermeable) or E2 induced the up-regulation of ER-alpha and GPR30 and attenuated hepatic injury. This was accompanied by increases in PKA activity and Bcl-2 expression. Inhibition of PKA in E2-BSA-treated trauma-hemorrhage rats by PKA inhibitor H89 prevented the E2-BSA attenuation of hepatic injury. Isolated hepatocytes were transfected with small interfering RNA to suppress GPR30 or ER. We found that suppression of GPR30 but not ER-alpha prevented E2-BSA- or E2-induced PKA activation and Bcl-2 expression. These results suggest that the nongenomic salutary effect of E2 in reducing hepatic injury after trauma-hemorrhage is mediated through the PKA-dependent pathway via GPR30 but not ER-alpha.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.