ArticleBMC structural biology2007
On the origin of the histone fold.
Article in BMC structural biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Review
- Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending.Nucleic acids research · 2024Article
- Multisubstrate specificity shaped the complex evolution of the aminotransferase family across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The role of cryptic ancestral symmetry in histone folding mechanisms across Eukarya and Archaea.PLoS computational biology · 2024Article
- Structome: a tool for the rapid assembly of datasets for structural phylogenetics.Bioinformatics advances · 2023Article
- Human FoxP Transcription Factors as Tractable Models of the Evolution and Functional Outcomes of Three-Dimensional Domain Swapping.International journal of molecular sciences · 2021Review
- The dark side of histones: genomic organization and role of oncohistones in cancer.Clinical epigenetics · 2021Review
- Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression.International journal of molecular sciences · 2020Review
- Article
- Linking in domain-swapped protein dimers.Scientific reports · 2016Article
- Article
- Article
- Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V.Journal of virology · 2014Article
- A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein.Journal of structural biology · 2014Article
- Article
- Conservation of the three-dimensional structure in non-homologous or unrelated proteins.Human genomics · 2012Review
- Intra-chain 3D segment swapping spawns the evolution of new multidomain protein architectures.Journal of molecular biology · 2012Article
- The impact of solubility and electrostatics on fibril formation by the H3 and H4 histones.Protein science : a publication of the Protein Society · 2011Article
- Experimental evidence for the role of domain swapping in the evolution of the histone fold.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The Histone Database: an integrated resource for histones and histone fold-containing proteins.Database : the journal of biological databases and curation · 2011Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHistones organize the genomic DNA of eukaryotes into chromatin. The four core histone subunits consist of two consecutive helix-strand-helix motifs and are interleaved into heterodimers with a unique fold. We have searched for the evolutionary origin of this fold using sequence and structure comparisons, based on the hypothesis that folded proteins evolved by combination of an ancestral set of peptides, the antecedent domain segments.
resultsOur results suggest that an antecedent domain segment, corresponding to one helix-strand-helix motif, gave rise divergently to the N-terminal substrate recognition domain of Clp/Hsp100 proteins and to the helical part of the extended ATPase domain found in AAA+ proteins. The histone fold arose subsequently from the latter through a 3D domain-swapping event. To our knowledge, this is the first example of a genetically fixed 3D domain swap that led to the emergence of a protein family with novel properties, establishing domain swapping as a mechanism for protein evolution.
conclusionThe helix-strand-helix motif common to these three folds provides support for our theory of an 'ancient peptide world' by demonstrating how an ancestral fragment can give rise to 3 different folds.
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