ArticleJournal of molecular evolution2007
A comparative genomics analysis of codon reassignments reveals a link with mitochondrial proteome size and a mechanism of genetic code change via suppressor tRNAs.
Article in Journal of molecular evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Disrupted architecture and fast evolution of the mitochondrial genome of Argeia pugettensis (Isopoda): implications for speciation and fitness.BMC genomics · 2020Article
- Rapid Genetic Code Evolution in Green Algal Mitochondrial Genomes.Molecular biology and evolution · 2019Article
- Chimeric Translation for Mitochondrial Peptides: Regular and Expanded Codons.Computational and structural biotechnology journal · 2019Article
- Blastocystis Mitochondrial Genomes Appear to Show Multiple Independent Gains and Losses of Start and Stop Codons.Genome biology and evolution · 2016Article
- Unbiased Mitoproteome Analyses Confirm Non-canonical RNA, Expanded Codon Translations.Computational and structural biotechnology journal · 2016Article
- Genetic code evolution reveals the neutral emergence of mutational robustness, and information as an evolutionary constraint.Life (Basel, Switzerland) · 2015Article
- What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?Journal of the Royal Society, Interface · 2013Article
- The Oxytricha trifallax mitochondrial genome.Genome biology and evolution · 2012Article
- The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes.Frontiers in genetics · 2012Article
- Termination of protein synthesis in mammalian mitochondria.The Journal of biological chemistry · 2011Review
- A deviant genetic code in the reduced mitochondrial genome of the picoplanktonic green alga Pycnococcus provasolii.Journal of molecular evolution · 2010Article
- Searching of code space for an error-minimized genetic code via codon capture leads to failure, or requires at least 20 improving codon reassignments via the ambiguous intermediate mechanism.Journal of molecular evolution · 2010Article
- Tandem stop codons in ciliates that reassign stop codons.Journal of molecular evolution · 2009Article
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Using a comparative genomics approach we demonstrate a negative correlation between the number of codon reassignments undergone by 222 mitochondrial genomes and the mitochondrial genome size, the number of mitochondrial ORFs, and the sizes of the large and small subunit mitochondrial rRNAs. In addition, we show that the TGA-to-tryptophan codon reassignment, which has occurred 11 times in mitochondrial genomes, is found in mitochondrial genomes smaller than those which have not undergone the reassignment. We therefore propose that mitochondrial codon reassignments occur in a wide range of phyla, particularly in Metazoa, due to a reduced "proteomic constraint" on the mitochondrial genetic code, compared to the nuclear genetic code. The reduced proteomic constraint reflects the small size of the mitochondrial-encoded proteome and allows codon reassignments to occur with less likelihood of lethality. In addition, we demonstrate a striking link between nonsense codon reassignments and the decoding properties of naturally occurring nonsense suppressor tRNAs. This suggests that natural preexisting nonsense suppression facilitated nonsense codon reassignments and constitutes a novel mechanism of genetic code change. These findings explain for the first time the identity of the stop codons and amino acids reassigned in mitochondrial and nuclear genomes. Nonsense suppressor tRNAs provided the raw material for nonsense codon reassignments, implying that the properties of the tRNA anticodon have dictated the identity of nonsense codon reassignments.
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