ArticleMolecular psychiatry2007
Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally infected mice.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 78 citations in OpenAlex.
- A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.JAMA psychiatry · 2013Trial
- Immune system inflammation in cocaine dependent individuals: implications for medications development.Human psychopharmacology · 2012Trial
- Neurobiological Mechanisms of Electroconvulsive Therapy: Molecular Perspectives of Brain Stimulation.International journal of molecular sciences · 2025Review
- A computational account of joint SSRI and anti-inflammatory treatment.Frontiers in immunology · 2025Article
- Glucocorticoids and the Brain after Critical Illness.Endocrinology · 2021Review
- Dorsal hippocampal interleukin-1 signaling mediates heroin withdrawal-enhanced fear learning.Psychopharmacology · 2020Article
- Stress-related suppression of peripheral cytokines predicts future relapse in alcohol-dependent individuals with and without subclinical depression.Addiction biology · 2020Article
- Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit.Experimental neurology · 2018Article
- Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β.Brain, behavior, and immunity · 2018Article
- Peripheral immune system suppression in early abstinent alcohol-dependent individuals: Links to stress and cue-related craving.Journal of psychopharmacology (Oxford, England) · 2017Article
- Peripheral Immune System Adaptations and Motivation for Alcohol in Non-Dependent Problem Drinkers.Alcoholism, clinical and experimental research · 2017Article
- The role of brain interleukin-1 in stress-enhanced fear learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- GWAS, cytomegalovirus infection, and schizophrenia.Current behavioral neuroscience reports · 2014Article
- Similar therapeutic efficacy between a single administration of gene therapy and multiple administrations of recombinant enzyme in a mouse model of lysosomal storage disease.Human gene therapy · 2014Article
- Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice.Frontiers in behavioral neuroscience · 2014Article
- Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice.Molecular psychiatry · 2013Article
- Glucocorticoid treatment of MCMV infected newborn mice attenuates CNS inflammation and limits deficits in cerebellar development.PLoS pathogens · 2013Article
- Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Essential role of interleukin-15 receptor in normal anxiety behavior.Brain, behavior, and immunity · 2010Article
- Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics.Annals of the New York Academy of Sciences · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Endogenous glucocorticoids restrain proinflammatory cytokine responses to immune challenges such as viral infection. In addition, proinflammatory cytokines induce behavioral alterations including changes in locomotor/exploratory activity. Accordingly, we examined proinflammatory cytokines and open-field behavior in virally infected mice rendered glucocorticoid deficient by adrenalectomy (ADX). Mice were infected with murine cytomegalovirus (MCMV), and open-field behavior (36 h post-infection) and plasma concentrations of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 (42 h post-infection) were assessed. Compared to sham-ADX-MCMV-infected animals, ADX-MCMV-infected mice exhibited significant reductions in total distance moved, number of center entries, and time spent in center. These behavioral alterations were accompanied by significantly higher plasma concentrations of TNF-alpha and IL-6, both of which were correlated with degree of behavioral change. To examine the role of TNF-alpha in these behavioral alterations, open-field behavior was compared in wild-type (WT) and TNF-R1-knockout (KO), ADX-MCMV-infected mice. TNF-R1-KO mice exhibited significantly attenuated decreases in number of rearings, number of center entries and time spent in center, but not distance moved, which correlated with plasma IL-6. Given the potential role of brain cytokines in these findings, mRNA expression of TNF-alpha, IL-1 and IL-6 was assessed in various brain regions. Although MCMV induced increases in proinflammatory cytokine mRNA throughout the brain (especially in ADX animals), no remarkable differences were found between WT and TNF-R1-KO mice. These results demonstrate that endogenous glucocorticoids restrain proinflammatory cytokine responses to viral infection and their impact on locomotor/exploratory activity. Moreover, TNF-alpha appears to mediate cytokine-induced changes in open-field behaviors, especially those believed to reflect anxiety.
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Registered trials
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