ArticleDementia and geriatric cognitive disorders2007
Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults.
Article in Dementia and geriatric cognitive disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 104 citations in OpenAlex.
- Alcohol use andAlzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging.Nutrition journal · 2024Article
- Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia.Cerebral circulation - cognition and behavior · 2024Article
- Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum.Brain : a journal of neurology · 2023Article
- Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes.Journal of Alzheimer's disease : JAD · 2023Article
- Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers.Brain imaging and behavior · 2022Article
- APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults.Hippocampus · 2021Article
- Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults.Hippocampus · 2021Article
- Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia.Frontiers in aging neuroscience · 2021Article
- Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.Brain imaging and behavior · 2020Article
- Effects of Smoking on Regional Homogeneity in Mild Cognitive Impairment: A Resting-State Functional MRI Study.Frontiers in aging neuroscience · 2020Article
- APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.NeuroImage · 2019Article
- Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture.Neurobiology of learning and memory · 2019Article
- Left Ventricular Mass, Brain Magnetic Resonance Imaging, and Cognitive Performance: Results From the Strong Heart Study.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Five-Year Longitudinal Brain Volume Change in Healthy Elders at Genetic Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Article
- Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China.Psychiatric genetics · 2016Article
- Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study.Neurology · 2016Article
- Spatial pattern separation differences in older adult carriers and non-carriers for the apolipoprotein E epsilon 4 allele.Neurobiology of learning and memory · 2016Article
- Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Article
- Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsBecause of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults.
methodsTwo groups ofolder adults, as determined by their APOE epsilon4 allele status, received structural MRI and comprehensive neuropsychological testing on two occasions separated on average by 17 months.
resultsCross-sectional comparisons by APOE group revealed no differences in hippocampal volumes, although longitudinal percent reduction in hippocampal volume was significantly greater for those possessing the APOE epsilon4 allele. Relationship between hippocampal volumes and memory performance was strongly impacted by diagnosis of mild cognitive impairment.
conclusionsAPOE epsilon4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults, and detailed cognitive characterization of the sample is necessary to reliably interpret the relationship between cognition and brain structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.