ArticleBMC cancer2007
Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis.International journal of colorectal disease · 2010Pooled it
- Review
- Low-Penetrance Susceptibility Variants in Colorectal Cancer-Current Outlook in the Field.International journal of molecular sciences · 2024Review
- Clinicopathological characteristics of breast cancer patients withContemporary oncology (Poznan, Poland) · 2020Article
- NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis.Cellular and molecular gastroenterology and hepatology · 2019Review
- Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis.Journal of biomedical science · 2018Review
- NOD2 mutations and colorectal cancer - Where do we stand?World journal of gastrointestinal surgery · 2016Review
- The intestinal microbiota: its role in health and disease.European journal of pediatrics · 2015Review
- 3020insC NOD2/CARD15 polymorphism associated with treatment of colorectal cancer.Medical oncology (Northwood, London, England) · 2014Article
- Risk modification of colorectal cancer susceptibility by interleukin-8 -251T>A polymorphism in Malaysians.World journal of gastroenterology · 2012Article
- CARD15 mutations and colorectal cancer in a South European country.International journal of colorectal disease · 2010Article
- Pathogen recognition receptors, cancer and inflammation in the gut.Current opinion in pharmacology · 2009Review
- Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.BMC gastroenterology · 2009Article
- Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk.BMC cancer · 2008Article
- The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation.Seminars in immunopathology · 2007Review
- The Association between Nod2 R702w Polymorphism and Susceptibility to Colorectal Cancer in Romanian Patients.Current health sciences journalArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer (CRC) and mutations of the NOD2/CARD15 gene increase the risk for Crohn's disease (CD). Recently, NOD2/CARD15 has been associated with a risk for CRC in some studies, which stemmed from ethnically diverse populations. Our aim was to identify common NOD2/CARD15 mutations in Hungarian patients with sporadic CRC.
methodsA total of 194 sporadic CRC patients (m/f: 108/86, age at diagnosis of CRC: 63.2 +/- 9.1 years old) and 200 healthy subjects were included. DNA was screened for SNP8, SNP12 and SNP13 NOD2/CARD15 mutations by denaturing-HPLC and confirmed by direct sequencing.
resultsNOD2/CARD15 mutations were found in 28 patients (14.4%) and in 23 controls (11.5%, p = NS). Allele frequencies for SNP8/R702W (1.8% vs. 1.5%) SNP12/G908R (1.8% vs. 1.8%) and SNP13/3020insC (3.6% vs. 2.5%) were also not statistically different between patients and controls. The clinicopathologic characteristics of CRC patients with or without NOD2/CARD15 mutations were not significantly different.
conclusionOur results suggest that common NOD2/CARD15 mutations alone do not contribute to CRC risk in the Hungarian population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.