ArticleJournal of thrombosis and haemostasis : JTH2007
Effect of wine phenolics on cytokine-induced C-reactive protein expression.
Article in Journal of thrombosis and haemostasis : JTH, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Abelmoschus manihot alleviates insulin resistance in diabetic kidney disease through attenuation of inflammation.BMC nephrology · 2025Article
- Red Wine and Sexual Function in Men: An Original Point of View.Journal of clinical medicine · 2023Article
- In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum.Molecules (Basel, Switzerland) · 2021Article
- Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications.Nutrients · 2020Review
- PTEN over-expression by resveratrol in acute lymphoblastic leukemia cells along with suppression of AKT/PKB and ERK1/2 in genotoxic stress.Journal of natural medicines · 2015Article
- Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression.Oncogene · 2014Article
- Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations.European journal of nutrition · 2013Article
- Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells.Molecular and cellular biochemistry · 2013Article
- Resveratrol, wine, and atherosclerosis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2012Article
- Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia.European journal of pharmacology · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElevation of C-reactive protein (CRP) levels in blood was recognized as one of the cardiac disease risk factors. Consumption of wine is shown to reduce the risk from heart disease and improve longevity.
objectivesIn the present study, we evaluated the effect of various wine polyphenolic compounds and several active synthetic derivatives of resveratrol on the inflammatory cytokines (IL-1beta + IL-6)-induced CRP expression in Hep3B cells.
resultsAmong the wine phenolics tested, quercetin and resveratrol, in a dose-dependent manner, suppressed cytokine-induced CRP expression. Two of the synthetic derivatives of resveratrol, R3 and 7b, elicited a fiftyfold higher suppressive effect compared with resveratrol. The inhibitory effects of resveratrol and its derivatives on CRP expression were at the level of mRNA production. Investigation of signaling pathways showed that the cytokines induced the phosphorylation of p38 and p44/42 MAP kinases. Inhibitors of p38 and p44/42 mitogen-activated protein kinase (MAPK) activation inhibited CRP expression, implicating the involvement of both pathways in cytokine-induced CRP expression. These data revealed a previously unrecognized role of the p44/42 MAPK signaling pathway in CRP expression. Wine polyphenolics or the synthetic compounds of resveratrol did not affect cytokine-activated phosphorylation of these MAPKs.
conclusionsWine phenolics inhibit CRP expression; however, to do so, they do not utilize the MAPK pathways.
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