ReviewPharmaceutical research2007
Cell and tissue targeting of nucleic acids for cancer gene therapy.
Review in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Targeting and functional effects of biomaterials-based nanoagents for acute pancreatitis treatment.Frontiers in bioengineering and biotechnology · 2022Review
- Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system.Asian journal of pharmaceutical sciences · 2020Article
- Calcium condensed LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells.Molecular pharmaceutics · 2011Article
- Magnetic nanoparticles as targeted delivery systems in oncology.Radiology and oncology · 2011Article
- Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation.Ultrasound in medicine & biology · 2010Article
- New core-shell nanoparticules for the intravenous delivery of siRNA to experimental thyroid papillary carcinoma.Pharmaceutical research · 2010Article
- Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival.Oncogene · 2009Article
- Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection.Journal of controlled release : official journal of the Controlled Release Society · 2009Article
- Exploiting the tumor microenvironment in the development of targeted cancer gene therapy.Cancer gene therapy · 2009Article
- Very long chain N4, N9 -diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA and siRNA delivery.Pharmaceutical research · 2009Article
- Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction.Journal of controlled release : official journal of the Controlled Release Society · 2008Review
- Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier.Bioconjugate chemistry · 2008Article
- Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides.Nucleic acids research · 2008Review
- Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer.Gene therapy · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor targeting--per definition--includes any strategy to improve the specificity of the therapeutic nucleic acid towards the tumor site, while highest biological activity should be maintained. Targeting has been successfully achieved at the transcriptional, transductional or delivery level. For tumor-specific delivery, physical targeting methods like electroporation, hyperthermia, magnetofection, photochemical internalization or ultrasound, and biological targeting systems, including active and passive tumor targeting, have been developed. Therapeutic effects could be demonstrated with various targeted nucleic acid formulations, such as tumor-targeted DNA plasmids expressing p53 or tumor necrosis factor alpha, small interfering RNAs knocking down gene expression from tumor specific chromosomal translocations or gene expression of tumor neoangiogenic processes, as well as double stranded RNA poly inosine-cytosine which triggers apoptosis in targeted tumor cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.