ArticlePathology oncology research : POR2007
Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas.
Article in Pathology oncology research : POR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 36 citations in OpenAlex.
- High expression of matrix metalloproteinases 16 is associated with the aggressive malignant behavior and poor survival outcome in colorectal carcinoma.Scientific reports · 2017Article
- MMP16 is a marker of poor prognosis in gastric cancer promoting proliferation and invasion.Oncotarget · 2016Article
- Exosomes as Tools to Suppress Primary Brain Tumor.Cellular and molecular neurobiology · 2016Review
- The Role of Mir-148a in Cancer.Journal of Cancer · 2016Review
- Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.Oncotarget · 2015Article
- Metastasis-associated in colon cancer 1 is a novel survival-related biomarker for human patients with renal pelvis carcinoma.PloS one · 2014Article
- Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis.Neuro-oncology · 2013Article
- MET gain in diffuse astrocytomas is associated with poorer outcome.Brain pathology (Zurich, Switzerland) · 2013Article
- Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.PloS one · 2013Article
- Long-term epilepsy-associated tumors.Brain pathology (Zurich, Switzerland) · 2012Review
- Genetic alterations in glioma.Cancers · 2011Article
- A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53.Journal of neuropathology and experimental neurology · 2011Article
- Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology.Neuro-oncology · 2010Article
- Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line.Pathology oncology research : POR · 2010Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To extend our understanding of potential stepwise genetic alterations that may underlie tumor progression from low-grade astrocytomas to glioblastomas, histopathologic and comparative genomic hybridization analyses were performed on tumor specimens from 68 primary lesions, including 40 glioblastomas, 10 anaplastic and 18 low-grade astrocytomas. The number of aberrations per case increased towards the higher grade tumors (grade II: 1.66+/-1.49; grade III: 2.80+/-1.68; grade IV: 3.02+/-1.07; F=6.955, p=0.002). A gain of 7/7q was common and the most frequently seen aberration in low-grade astrocytomas, whereas loss of 10q was the most frequently seen anomaly in anaplastic astrocytomas and glioblastomas. Chromosome 7p amplification was only detected in glioblastomas. Chromosome 10/10q deletion and combination of 1p, 19q and 17p deletions were specific to high-grade astrocytic tumors. Sequences of chromosome 7 and 10 seem to have pivotal roles in the biology of human gliomas. The genomic copy deletions of chromosomes 1p and 19q might provide an alternative mechanism in the genesis of astrocytomas.
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