ArticleBritish journal of cancer2007
The negative association between pre-eclampsia and breast cancer risk may depend on the offspring's gender.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population-based case-control study.International journal of cancer · 2018Article
- Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.International journal of cancer · 2018Article
- State of the evidence 2017: an update on the connection between breast cancer and the environment.Environmental health : a global access science source · 2017Review
- Pregnancy-related characteristics and breast cancer risk.Cancer causes & control : CCC · 2013Article
- Pre-eclampsia and long-term maternal health.Obstetric medicine · 2012Review
- Hypertensive diseases in pregnancy and breast cancer risk.British journal of cancer · 2012Article
- Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies.Cancer causes & control : CCC · 2012Article
- The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic?European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2011Review
- Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature.Cancer causes & control : CCC · 2010Review
- Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk.Cancer research · 2008Article
- Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?British journal of cancer · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
If the negative association between pre-eclampsia and subsequent breast cancer risk differs by gender, this would strengthen the hypothesis that factors intrinsic to the particular pregnancy may explain the association. The study included 701,006 parous Norwegian women with follow-up for breast cancer through the Cancer Registry of Norway. Breast cancer risk was lower in women with pre-eclampsia/hypertension in their first pregnancy, compared to other women (relative risk, 0.86, 95% CI, 0.78-0.94), after adjustment for age at first birth, maternal birth year, length of gestation, marital status, and parity. The risk reduction was slightly greater if the woman delivered a son as opposed to a daughter (relative risks of 0.79 vs 0.94, P-value for interaction, 0.06), and if pre-eclampsia/hypertension was combined with pre-term delivery, these differences were more pronounced (relative risks, 0.62 vs 1.07, P-value for interaction 0.03). A subanalysis among 176,036 primiparous women showed a substantial risk reduction if the mother delivered a son (relative risk, 0.62, 95% CI, 0.47-0.82), but essentially null if she delivered a daughter (relative risk, 0.92, 95% CI, 0.72-1.18; P-value for interaction, 0.05). These results suggest that the effect of pre-eclampsia/hypertension may be attributed to factors associated with the particular pregnancy rather than an underlying biological trait of the mother. The stronger risk reduction related to having a son suggests a role for sex-dependent hormones in pregnancy.
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