ArticleMolecular and cellular biology2007
The Tup1 corepressor directs Htz1 deposition at a specific promoter nucleosome marking the GAL1 gene for rapid activation.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.Genetics · 2021Article
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- Metabolic transcriptional memory.Molecular metabolism · 2020Review
- Epigenetic Transcriptional Memory ofGenetics · 2017Article
- Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate.Journal of molecular biology · 2017Review
- Sumoylation controls the timing of Tup1-mediated transcriptional deactivation.Nature communications · 2015Article
- Sumoylation and transcription regulation at nuclear pores.Chromosoma · 2015Review
- The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene.Biochimica et biophysica acta · 2014Article
- Distinct roles for histone chaperones in the deposition of Htz1 in chromatin.Bioscience reports · 2014Article
- Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa.PloS one · 2014Article
- A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory.PLoS biology · 2013Article
- The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.Genes & development · 2011Article
- Key functional regions in the histone variant H2A.Z C-terminal docking domain.Molecular and cellular biology · 2011Article
- Histone variant H2A.Z and RNA polymerase II transcription elongation.Molecular and cellular biology · 2011Article
- Genetic analysis implicates the Set3/Hos2 histone deacetylase in the deposition and remodeling of nucleosomes containing H2A.Z.Genetics · 2011Article
- Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory.Molecular cell · 2010Article
- Corepressor-directed preacetylation of histone H3 in promoter chromatin primes rapid transcriptional switching of cell-type-specific genes in yeast.Molecular and cellular biology · 2010Article
- Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory.PLoS biology · 2010Article
- Dominant role for signal transduction in the transcriptional memory of yeast GAL genes.Molecular and cellular biology · 2010Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The SWR1 complex (SWR1-C)-dependent deposition of the histone variant Htz1 on promoter nucleosomes is typical of Saccharomyces cerevisiae genes whose expression is frequently reprogrammed. Although this epigenetic marking is of significant physiological importance, the determinants of Htz1 deposition, the conditions that set off SWR1-C occupancy, and the implications of Htz1 in transcriptional initiation are issues that remain unresolved. In this report, we addressed these questions by investigating the GAL1 promoter. We show that Htz1 is required for efficient Mediator recruitment and transcription only when the GAL1 promoter is under the influence of the Tup1 corepressor. In fact, we show that it is Tup1 that specifies Htz1 deposition for the promoter nucleosome covering the transcription start site. This deposition occurs rapidly following transcriptional repression, and it correlates with a Tup1-independent transient recruitment of the SWR1 complex. We propose that Tup1 cooperates with SWR1-C and specifies Htz1 deposition at GAL1, thereby marking the promoter for rapid neutralization from its repressive effects.
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