ArticleGenome research2007
The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Biological characteristics of ATP5A1 and its pathogenic mechanisms in human diseases: advances in clinical translation.Frontiers in cell and developmental biology · 2026Review
- Dominant-Negative Form of SIGIRR: SIGIRRJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Article
- A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency.European journal of human genetics : EJHG · 2021Article
- Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.BMC infectious diseases · 2021Article
- Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation.BMC cancer · 2020Article
- Identification of ATP synthase α subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in ApcMammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Ovarian transcriptomic analysis of Shan Ma ducks at peak and late stages of egg production.Asian-Australasian journal of animal sciences · 2017Article
- Colitis-associated colon cancer: Is it in your genes?World journal of gastroenterology · 2015Review
- Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis.Genetics · 2014Article
- A strategy to identify dominant point mutant modifiers of a quantitative trait.G3 (Bethesda, Md.) · 2014Article
- The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients.Hereditary cancer in clinical practice · 2013Article
- Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.PLoS genetics · 2013Article
- More than two decades of Apc modeling in rodents.Biochimica et biophysica acta · 2013Review
- Understanding phenotypic variation in rodent models with germline Apc mutations.Cancer research · 2013Review
- Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain.Carcinogenesis · 2012Article
- A method for non-invasive genotyping of APCmin/+ mice using fecal samples.Biological procedures online · 2012Article
- The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function.Toxicology and applied pharmacology · 2011Article
- Animal models of human genetic diseases: do they need to be faithful to be useful?Molecular genetics and genomics : MGG · 2011Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Inactivation of the APC gene is considered the initiating event in human colorectal cancer. Modifier genes that influence the penetrance of mutations in tumor-suppressor genes hold great potential for preventing the development of cancer. The mechanism by which modifier genes alter adenoma incidence can be readily studied in mice that inherit mutations in the Apc gene. We identified a new modifier locus of ApcMin-induced intestinal tumorigenesis called Modifier of Min 2 (Mom2). The polyp-resistant Mom2R phenotype resulted from a spontaneous mutation and linkage analysis localized Mom2 to distal chromosome 18. To obtain recombinant chromosomes for use in refining the Mom2 interval, we generated congenic DBA.B6 ApcMin/+, Mom2R/+ mice. An intercross revealed that Mom2R encodes a recessive embryonic lethal mutation. We devised an exclusion strategy for mapping the Mom2 locus using embryonic lethality as a method of selection. Expression and sequence analyses of candidate genes identified a duplication of four nucleotides within exon 3 of the alpha subunit of the ATP synthase (Atp5a1) gene. Tumor analyses revealed a novel mechanism of polyp suppression by Mom2R in Min mice. Furthermore, we show that more adenomas progress to carcinomas in Min mice that carry the Mom2R mutation. The absence of loss of heterozygosity (LOH) at the Apc locus, combined with the tendency of adenomas to progress to carcinomas, indicates that the sequence of events leading to tumors in ApcMin/+ Mom2R/+ mice is consistent with the features of human tumor initiation and progression.
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