ArticleDNA repair2007
p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G.
Article in DNA repair, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Multi-omic screening identifies RBMXL3 as a primate-specific RNA-binding protein and candidate regulator of RNA metabolism in human spermatogenesis.Cellular & molecular biology letters · 2026Article
- [RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Association between ankylosing spondylitis and m6A methylation.Journal of orthopaedic surgery and research · 2023Article
- Virus usurps alternative splicing to clear the decks for infection.Virology journal · 2023Review
- DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders.International journal of molecular sciences · 2022Review
- High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation.Frontiers in cellular and infection microbiology · 2022Review
- Review
- New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response.Frontiers in molecular biosciences · 2021Review
- Maintenance of genome stability: the unifying role of interconnections between the DNA damage response and RNA-processing pathways.Current genetics · 2018Review
- RNA Binding Proteins and Genome Integrity.International journal of molecular sciences · 2017Review
- Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.Carcinogenesis · 2016Article
- The RNA Splicing Response to DNA Damage.Biomolecules · 2015Review
- Expression of RBMX in the light-induced damage of rat retina in vivo.Cellular and molecular neurobiology · 2015Article
- The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability.Frontiers in genetics · 2015Article
- Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation.Nucleic acids research · 2014Article
- Article
- Expression of RBMX after spinal cord injury in rats.Journal of molecular neuroscience : MN · 2013Article
- Article
- A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.Nature cell biology · 2012Article
- Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer.Oral oncology · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Many studies have suggested the involvement of wild-type (wt) p53 in the repair of DNA double-strand breaks (DSBs) via DNA end-joining (EJ) process. To investigate this possibility, we compared the capacity and fidelity of DNA EJ in RKO cells containing wt p53 and RKO cells containing no p53 (RKO cells with p53 knockdown). The p53 knockdown cells showed lower fidelity of DNA EJ compared to the control RKO cells. The DNA end-protection assay revealed the association of a protein complex including heterogeneous nuclear ribonucleoprotein G (hnRNP G) with the DNA ends in RKO cells containing wt p53, but not with the DNA ends in RKO cells with p53 knockdown. Depletion of endogenous hnRNP G notably diminished the fidelity of EJ in RKO cells expressing wt p53. Moreover, an ectopic expression of hnRNP G significantly enhanced the fidelity of DNA EJ and the protection of DNA ends in human cancer cells lacking hnRNP G protein or containing mutant hnRNP G. Finally, using recombinant hnRNP G proteins, we demonstrated the hnRNP G protein is able to bind to and protect DNA ends from degradation of nucleases. Our results suggest that wt p53 modulates DNA DSB repair by, in part, inducing hnRNP G, and the ability of hnRNP G to bind and protect DNA ends may contribute its ability to promote the fidelity of DNA EJ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.