ReviewSeminars in immunology2007
Transcriptional regulation of T cell tolerance.
Review in Seminars in immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Protein ubiquitination in T cell development.Frontiers in immunology · 2022Review
- Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism.The Journal of pharmacology and experimental therapeutics · 2017Article
- Nuclear calcium is required for human T cell activation.The Journal of cell biology · 2016Article
- Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response.Journal of immunology research · 2016Review
- Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity.Vaccines · 2015Review
- Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.Frontiers in immunology · 2015Review
- Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.EMBO reports · 2014Article
- Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.Molecular and cellular biology · 2014Article
- Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- FoxO-dependent regulation of diacylglycerol kinase α gene expression.Molecular and cellular biology · 2012Article
- Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells.European journal of immunology · 2012Article
- Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis.Experimental & molecular medicine · 2012Article
- Molecular mechanisms of treg-mediated T cell suppression.Frontiers in immunology · 2012Article
- Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.Journal of leukocyte biology · 2010Article
- Plasticity in programming of effector and memory CD8 T-cell formation.Immunological reviews · 2010Review
- ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond.Immunological reviews · 2009Review
- Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance.The Journal of experimental medicine · 2009Article
- IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.Molecular immunology · 2009Article
- Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells.Immunity · 2008Article
- Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data.BMC systems biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Self-reactive T cells that escape negative selection in the thymus must be kept under control in the periphery. Mechanisms of peripheral tolerance include deletion or functional inactivation of self-reactive T cells and mechanisms of dominant tolerance mediated by regulatory T cells. In the absence of costimulation, T cell receptor (TCR) engagement results in unopposed calcium signaling that leads to the activation of a cell-intrinsic program of inactivation, which makes T cells hyporesponsive to subsequent stimulations. The activation of this program in anergic T cells is a consequence of the induction of a nuclear factor of activated T cells (NFAT)-dependent program of gene expression. Recent studies have offered new insights into the mechanisms responsible for the implementation and maintenance of T cell anergy and have provided evidence that the proteins encoded by the genes upregulated in anergic T cells are responsible for the implementation of anergy by interfering with TCR signaling or directly inhibiting cytokine gene transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.