Evidence map›Paper›PMID 17385083›Full record

ArticleJournal of neurology2007

An attempt to investigate the presence of Epstein Barr virus in multiple sclerosis and normal control brain tissue.

Margaret L Opsahl, Peter G E Kennedy

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Molecular signature of Epstein-Barr virus infection in MS brain lesions.Neurology(R) neuroimmunology & neuroinflammation · 2018
    Article
  7. Article
  8. Review
  9. Viruses and multiple sclerosis.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011
    Review
  10. Viral pathophysiology of multiple sclerosis: A role for Epstein-Barr virus infection?Pathophysiology : the official journal of the International Society for Pathophysiology · 2011
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 3 countries.

Margaret L OpsahlUniversity of Glasgow, Dept. of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences Southern General Hospital, Glasgow G51 4TF (Scotland), UK.
Peter G E Kennedy
University of Glasgow · GB

Funding

Multiple Sclerosis Society 559
6 · The paper itself

Abstract

Multiple Sclerosis (MS) is an important demyelinating disease of the central nervous system, the aetiology of which may possibly have a viral component at some stage. In this study we investigated the possible involvement in MS of the human herpes virus Epstein Barr Virus (EBV). Utilising both fluorescent and non-fluorescent in situ hybridisation (FISH) techniques, we examined human post mortem tissues obtained from a tissue bank for the presence of immediate early and late viral gene and protein expression in MS patient normal appearing white matter (NAWM), lesional tissue and normal control brain samples. The technique of mRNA FISH showed that many of the tissues were largely degraded and therefore could not provide any evidence of viral gene expression. Some weak scattered signals, however, were seen in mRNA ISH for both lytic and latent gene transcription in all three tissue categories. The failure of IF and mRNA FISH in the majority of samples alongside the poor signal for mRNA ISH precluded any definite conclusions to be made as to the possible ongoing involvement of EBV in MS. While certainly not ruling out a possible role of EBV in MS, especially in the context of a 'hit and run' mechanism, these studies illustrate the difficulties of using autopsy tissues for molecular studies when tissue preservation is sub-optimal. Nevertheless, the limited data obtained did not provide any positive evidence of EBV involvement.

Indexed as

AgedAged, 80 and overFemaleHerpesvirus 4, HumanHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerViral ProteinsRNA, MessengerViral Proteins

Identifiers

PMID17385083
OpenAlexW1982686463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.