ArticleLangenbeck's archives of surgery2007
Sirolimus impairs wound healing.
Article in Langenbeck's archives of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Topical ROCEN (nanoliposomal avocado/soybean unsaponifiables) enhances survival of random-pattern skin flaps through Akt/mTOR pathway modulation.Molecular biology reports · 2025Article
- Risk factors for incisional hernia after liver transplantation in the era of mammalian target of rapamycin inhibitors use: a retrospective study of living donor liver transplantation dominant center in Korea.Annals of surgical treatment and research · 2024Article
- [Role and mechanism of Vγ4 T cells in impaired wound healing of rapamycin-induced full-thickness skin defects in mice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Mammalian Target of Rapamycin Inhibitors and Wound Healing Complications in Kidney Transplantation: Old Myths and New Realities.Journal of transplantation · 2022Review
- Costimulation Blockade in Vascularized Composite Allotransplantation.Frontiers in immunology · 2020Review
- Cyclodextrin Polymer Preserves Sirolimus Activity and Local Persistence for Antifibrotic Delivery over the Time Course of Wound Healing.Molecular pharmaceutics · 2019Article
- mTORC2 deficiency in cutaneous dendritic cells potentiates CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- [Effects of rapamycin and deferoxamin on wound healing after ischemia and hypoxia].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Article
- AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes.Scientific reports · 2016Article
- A derangement of the brain wound healing process may cause some cases of Alzheimer's disease.Discovery medicine · 2016Article
- Growth hormone abolishes the negative effects of everolimus on intestinal wound healing.World journal of gastroenterology · 2016Article
- Sirolimus conversion efficacy for graft function improvement and histopathology in renal recipients with mild to moderate renal insufficiency.Journal of Korean medical science · 2014Article
- [Multimodal oncological therapy concepts, chemotherapy and immunosuppressive drugs: effects on surgical morbidity and mortality].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2013Review
- Free tissue transfer for head and neck reconstruction in solid organ transplant patients.Head & neck · 2012Article
- Immunomodulation at epithelial sites by obesity and metabolic disease.Immunologic research · 2012Review
- Protective measures against ultrafiltration failure in peritoneal dialysis patients.Clinics (Sao Paulo, Brazil) · 2011Review
- Impaired lower extremity wound healing secondary to sirolimus after kidney transplantation.The journal of the American College of Certified Wound Specialists · 2009Article
- Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Rapamycin affects early fracture healing in mice.British journal of pharmacology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsClinically, the immunosuppressive drug sirolimus, used in organ transplantation, appears to impair wound healing. Little is known about the mechanisms of action. We investigated the effect of sirolimus on wound healing, and we analyzed the expression of stimulating mediators of angiogenesis (VEGF, vascular endothelial growth factor) and collagen synthesis (nitric oxide) in wounds. MATERIALS AND
methodsGroups of ten rats underwent dorsal skin incision, and polyvinyl alcohol sponges were implanted subcutaneously. Beginning at the day of wounding, rats were treated with 0.5, 2.0, or 5.0 mg sirolimus/kg/day. Animals were killed 10 days later to determine wound breaking strength and reparative collagen deposition. Expression of VEGF and nitric oxide was studied in wounds.
resultsSplenic lymphocyte proliferative activity was significantly decreased by sirolimus (p < 0.05). Sirolimus levels in wound fluid were found to be approximately two- to fivefold higher than blood levels (p < 0.01). Sirolimus (2.0 and 5.0 mg kg(-1) day(-1)) reduced wound breaking strength (p < 0.01) and wound collagen deposition (p < 0.05). This was paralleled by decreased expression of VEGF and nitric oxide in wounds.
conclusionExperimentally, our data show that sirolimus impairs wound healing, and this is reflected by diminished expression of VEGF and nitric oxide in the wound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.