ArticlePsychopharmacology2007
Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: A long and winding road.Drug discovery today · 2021Review
- Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice.Psychopharmacology · 2018Article
- Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.PloS one · 2017Article
- The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine HFrontiers in pharmacology · 2016Article
- Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine.Psychopharmacology · 2011Article
- A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.Psychopharmacology · 2011Article
- DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer.CNS neuroscience & therapeutics · 2010Article
- Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine.The international journal of neuropsychopharmacology · 2010Article
- Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats.Psychopharmacology · 2009Article
- Improvement of contextual memory by S 24795 in aged mice: comparison with memantine.Psychopharmacology · 2008Article
- Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets.Current medicinal chemistry · 2008Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study compared the effects of S 18986, a positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors, to those of donepezil a cholinesterase inhibitor on memory impairments induced by ageing in a contextual serial discrimination (CSD) task in middle-aged mice. MATERIALS AND
methodsThe CSD task involved the learning of two consecutive discriminations in a four-hole board, each performed on two different floors. This model has been developed to study simultaneously different forms of memory in mice (i.e., episodic-like vs semantic-like forms of memory). We showed that placebo-middle-aged mice (14-15 months old) and placebo-aged subjects (19-20 months old) exhibited a severe memory deficit for the first but not the second discrimination, which was due to an increase in interference, as compared with placebo-treated young mice (5 months old). Middle-aged mice were given (9 days) per os administration of either donepezil, S 18986, or placebo. RESULTS AND DISCUSSION: Both 0.3 mg/kg donepezil and 0.1 mg/kg S 18986 reversed the deficit of middle-aged mice through a significant increase in contextually correct responses and in parallel a tendency to reduce interfering responses.
conclusionOverall, S 18986 emerges as having a beneficial impact on contextual memory processes in middle-aged mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.