ArticleEukaryotic cell2007
DNA sequence characterization and molecular evolution of MAT1 and MAT2 mating-type loci of the self-compatible ascomycete mold Neosartorya fischeri.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 114 citations in OpenAlex.
- Homothallic or Heterothallic? A Genomic Investigation Into the Sexual Capabilities of the Ascomycete Fungus Clonostachys rosea.Molecular ecology · 2026Article
- Rethinking asexuality: the enigmatic case of functional sexual genes in Lepraria (Stereocaulaceae).BMC genomics · 2024Article
- Structure and number of mating pheromone genes is closely linked to sexual reproductive strategy in Huntiella.BMC genomics · 2023Article
- Insight into the evolutionary and domesticated history of the most widely cultivated mushroom Agaricus bisporus via mitogenome sequences of 361 global strains.BMC genomics · 2023Article
- Comparative Genomics Reveals Evolutionary Traits, Mating Strategies, and Pathogenicity-Related Genes Variation ofFrontiers in microbiology · 2022Article
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- The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata.BMC genomics · 2019Article
- Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis.Fungal genetics and biology : FG & B · 2019Article
- Unravelling species boundaries in thePersoonia · 2018Article
- Evolution of asexual and sexual reproduction in the aspergilli.Studies in mycology · 2018Article
- The Role of Transposable Elements in Speciation.Genes · 2018Review
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- Sexual Reproduction in Dermatophytes.Mycopathologia · 2017Article
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- Analysis of theMycobiology · 2016Article
- Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses.BMC genomics · 2016Article
- A barrier to homologous recombination between sympatric strains of the cooperative soil bacterium Myxococcus xanthus.The ISME journal · 2016Article
- Comparative genomic and transcriptomic analyses of the Fuzhuan brick tea-fermentation fungus Aspergillus cristatus.BMC genomics · 2016Article
- Genetic Dissection of Sexual Reproduction in a Primary Homothallic Basidiomycete.PLoS genetics · 2016Article
- Article
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3 authors at 2 institutions in 2 countries.
Funding
Abstract
Degenerate PCR and chromosome-walking approaches were used to identify mating-type (MAT) genes and flanking regions from the homothallic (sexually self-fertile) euascomycete fungus Neosartorya fischeri, a close relative of the opportunistic human pathogen Aspergillus fumigatus. Both putative alpha- and high-mobility-group-domain MAT genes were found within the same genome, providing a functional explanation for self-fertility. However, unlike those in many homothallic euascomycetes (Pezizomycotina), the genes were not found adjacent to each other and were termed MAT1 and MAT2 to recognize the presence of distinct loci. Complete copies of putative APN1 (DNA lyase) and SLA2 (cytoskeleton assembly control) genes were found bordering the MAT1 locus. Partial copies of APN1 and SLA2 were also found bordering the MAT2 locus, but these copies bore the genetic hallmarks of pseudogenes. Genome comparisons revealed synteny over at least 23,300 bp between the N. fischeri MAT1 region and the A. fumigatus MAT locus region, but no such long-range conservation in the N. fischeri MAT2 region was evident. The sequence upstream of MAT2 contained numerous candidate transposase genes. These results demonstrate a novel means involving the segmental translocation of a chromosomal region by which the ability to undergo self-fertilization may be acquired. The results are also discussed in relation to their significance in indicating that heterothallism may be ancestral within the Aspergillus section Fumigati.
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