ArticlePlant physiology2007
ELF4 is required for oscillatory properties of the circadian clock.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
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- Red Light Resets the Expression Pattern, Phase, and Period of the Circadian Clock in Plants: A Computational Approach.Biology · 2022Article
- Cellular localization of Arabidopsis EARLY FLOWERING3 is responsive to light quality.Plant physiology · 2022Article
- Role of Circadian Rhythms in Major Plant Metabolic and Signaling Pathways.Frontiers in plant science · 2022Review
- Genome-Wide Analysis of the MADS-Box Gene Family in Holoparasitic Plants (Frontiers in plant science · 2022Article
- Long-Term High-Temperature Stress Impacts on Embryo and Seed Development inFrontiers in plant science · 2022Article
- Phytochrome A elevates plant circadian-clock components to suppress shade avoidance in deep-canopy shade.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Genome-Wide Identification of theFrontiers in genetics · 2021Article
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- Shade signals alter the expression of circadian clock genes in newly-formed bioenergy sorghum internodes.Plant direct · 2020Article
- A mobile ELF4 delivers circadian temperature information from shoots to roots.Nature plants · 2020Article
- A simplified modelling framework facilitates more complex representations of plant circadian clocks.PLoS computational biology · 2020Article
- Chemical Perturbation of Chloroplast-Related Processes Affects Circadian Rhythms of Gene Expression inFrontiers in physiology · 2020Article
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- Luciferase-Based Screen for Post-translational Control Factors in the Regulation of the Pseudo-Response Regulator PRR7.Frontiers in plant science · 2019Article
- 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System.Plant physiology · 2018Article
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11 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Circadian clocks are required to coordinate metabolism and physiology with daily changes in the environment. Such clocks have several distinctive features, including a free-running rhythm of approximately 24 h and the ability to entrain to both light or temperature cycles (zeitgebers). We have previously characterized the EARLY FLOWERING4 (ELF4) locus of Arabidopsis (Arabidopsis thaliana) as being important for robust rhythms. Here, it is shown that ELF4 is necessary for at least two core clock functions: entrainment to an environmental cycle and rhythm sustainability under constant conditions. We show that elf4 demonstrates clock input defects in light responsiveness and in circadian gating. Rhythmicity in elf4 could be driven by an environmental cycle, but an increased sensitivity to light means the circadian system of elf4 plants does not entrain normally. Expression of putative core clock genes and outputs were characterized in various ELF4 backgrounds to establish the molecular network of action. ELF4 was found to be intimately associated with the CIRCADIAN CLOCK-ASSOCIATED1 (CCA1)/LONG ELONGATED HYPOCOTYL (LHY)-TIMING OF CAB EXPRESSION1 (TOC1) feedback loop because, under free run, ELF4 is required to regulate the expression of CCA1 and TOC1 and, further, elf4 is locked in the evening phase of this feedback loop. ELF4, therefore, can be considered a component of the central CCA1/LHY-TOC1 feedback loop in the plant circadian clock.
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