ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2007
Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 79 citations in OpenAlex.
- Multiple Cell Signalling Pathways of Human Proinsulin C-Peptide in Vasculopathy Protection.International journal of molecular sciences · 2020Review
- VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases.Vision research · 2017Review
- Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.Life sciences · 2016Article
- Endothelial Cell Redox Regulation of Ischemic Angiogenesis.Journal of cardiovascular pharmacology · 2016Review
- Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability.Molecular and cellular biochemistry · 2016Article
- Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy.World journal of diabetes · 2015Review
- Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1).Angiogenesis · 2015Article
- Increased Oxidative and Nitrative Stress Accelerates Aging of the Retinal Vasculature in the Diabetic Retina.PloS one · 2015Article
- NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy.Journal of diabetes research · 2015Article
- Primary retinal cultures as a tool for modeling diabetic retinopathy: an overview.BioMed research international · 2015Review
- Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin.Microvascular research · 2014Article
- Cerebral neovascularization in diabetes: implications for stroke recovery and beyond.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.Antioxidants & redox signaling · 2013Article
- Protein nitration impairs the myogenic tone of rat middle cerebral arteries in both ischemic and nonischemic hemispheres after ischemic stroke.American journal of physiology. Heart and circulatory physiology · 2013Article
- Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.British journal of pharmacology · 2013Review
- Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels.The Journal of pharmacology and experimental therapeutics · 2013Article
- Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.Journal of diabetes research · 2013Article
- Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment.PloS one · 2013Article
- Signaling pathways triggered by oxidative stress that mediate features of severe retinopathy of prematurity.JAMA ophthalmology · 2013Article
- Mechanisms and management of retinopathy of prematurity.The New England journal of medicine · 2012Review
Corrections and comments
- Retraction · 2017-01-01Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution ·
- Commented on by
- RetractedRetraction.2017
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The modulation of angiogenic signaling by reactive oxygen species (ROS) is an emerging area of interest in cellular and vascular biology research. We provide evidence here that peroxynitrite, the powerful oxidizing and nitrating free radical, is critically involved in transduction of the VEGF signal. We tested the hypothesis that VEGF induces peroxynitrite formation, which causes tyrosine phosphorylation and mediates endothelial cell migration and tube formation, by studies of vascular endothelial cells in vitro and in a model of hypoxia-induced neovascularization in vivo. The specific peroxynitrite decomposition catalyst FeTPPs blocked VEGF-induced phosphorylation of VEGFR2 and c-Src and inhibited endothelial cell migration and tube formation. Furthermore, exogenous peroxynitrite mimicked VEGF activity in causing phosphorylation of VEGFR2 and stimulating endothelial cell growth and tube formation in vitro and new blood vessel growth in vivo. The selective nitration inhibitor epicatechin enhanced VEGF's angiogenic function in activating VEGFR2, c-Src, and promoting endothelial cell growth, migration, and tube formation in vitro and retinal neovascularization in vivo. Decomposing peroxynitrite with FeTPPs or blocking oxidation using the thiol donor NAC blocked VEGF's angiogenic functions in vitro and in vivo. In conclusion, peroxynitrite is critically involved in transducing VEGF's angiogenic signal via nitration-independent and oxidation-mediated tyrosine phosphorylation.
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Registered trials
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