ArticleThe Journal of pediatrics2007
Neonatal hydrocortisone treatment: neurodevelopmental outcome and MRI at school age in preterm-born children.
Article in The Journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07248761 (Efficacy of Early Administration of Hydrocortisone in Shock in Preterm Neonates of Less Than 1,500 g), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Early Administration of Hydrocortisone in Shock in Preterm Neonates of Less Than 1,500 g
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Follow-Up of a Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Neurodevelopmental Outcomes of Extremely Preterm Infants Randomized to Stress Dose Hydrocortisone.PloS one · 2015Trial
- Pilot randomized trial of hydrocortisone in ventilator-dependent extremely preterm infants: effects on regional brain volumes.The Journal of pediatrics · 2013Trial
- Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial.BMC pediatrics · 2011Trial
- Cumulative Hydrocortisone Exposure and Early Brain Volumetrics in Very Low Birth Weight Infants: Associations with Neurodevelopmental Outcomes.Biomedicines · 2025Article
- Neurodevelopmental Outcome at 20 Months Corrected Age in Extremely Preterm Infants After Exposure to Dexamethasone and Hydrocortisone in the NICU.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Neurodevelopment at 24 months corrected age in extremely preterm infants treated with dexamethasone alternatives during the late postnatal period: a cohort study.European journal of pediatrics · 2024Observational
- Does the Degree of Prematurity Relate to theJournal of Intelligence · 2023Article
- Effects of postnatal glucocorticoids on brain structure in preterm infants, a scoping review.Neuroscience and biobehavioral reviews · 2023Article
- Screening for drugs potentially interfering with MCT8-mediated TJournal of endocrinological investigation · 2022Article
- Incidence, Predictors and Outcomes of Noninvasive Ventilation Failure in Very Preterm Infants.Children (Basel, Switzerland) · 2022Article
- Duration of mechanical ventilation is more critical for brain growth than postnatal hydrocortisone in extremely preterm infants.European journal of pediatrics · 2021Article
- Hydrocortisone and bronchopulmonary dysplasia: variables associated with response in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Bronchopulmonary dysplasia: Pathogenesis and treatment.Experimental and therapeutic medicine · 2018Review
- Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network.Seminars in perinatology · 2016Review
- Safety, efficacy and response to a hydrocortisone rescue therapy protocol in children with refractory hypotension after cardiopulmonal bypass.Pediatric cardiology · 2015Article
- Neurodevelopmental impact of hydrocortisone exposure in extremely low birth weight infants: outcomes at 1 and 2 years.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Evidence for adverse effect of perinatal glucocorticoid use on the developing brain.Korean journal of pediatrics · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate neurodevelopment at school age in preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) in the neonatal period. STUDY
designPreterm infants (n = 226; gestational age < or = 32 weeks and/or body weight < or = 1500 grams) performed subtests of the Wechsler Intelligence Scale for Children-Revised, the Visual Motor Integration test, a 15-Word Memory Test and the Movement Assessment Battery for Children at school age. Conventional MRI of the brain was obtained. Sixty-two children who received hydrocortisone for BPD (starting dose, 5 mg/kg/day; median duration, 27.5 days) were compared with 164 nontreated neonates.
resultsHydrocortisone-treated infants were younger, lighter, and sicker than their non-steroid-treated counterparts. Adjustments for gestational age, body weight, sex, mechanical ventilation, and small for gestational age were made. Adjusted mean Intelligence Quotient, Visual Motor Integration test, and memory test results were the same in the hydrocortisone-treated group and the non-steroid-treated group (99 versus 101, P = .62; 97 versus 99, P = .49, 7.9 versus 7.5, P = .42, respectively). Motor function and incidence of cerebral palsy in both groups was not different (11% versus 7%, P = .97). Occurrence of brain lesions on MRI was similar for the two groups.
conclusionsNeonatal hydrocortisone treatment for BPD had no long-term effects on neurodevelopment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.