ArticlePLoS pathogens2007
Drosophila eiger mutants are sensitive to extracellular pathogens.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed.
- TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae.PLoS pathogens · 2025Article
- Trypanosoma cruzi reprograms mitochondrial metabolism within the anterior midgut of its vector Rhodnius prolixus during the early stages of infection.Parasites & vectors · 2024Article
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- Review
- PcEiger links the Imd/Relish pathway to ROS production in the intestine of the red swamp crayfish.EMBO reports · 2023Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- Immunometabolic regulation during the presence of microorganisms and parasitoids in insects.Frontiers in immunology · 2023Review
- Review
- Variation of TNF modulates cellular immunity of gregarious and solitary locusts against fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phagocytosis Is the Sole Arm ofFrontiers in immunology · 2022Article
- A Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence.Frontiers in immunology · 2022Article
- Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites.Immunology · 2021Review
- The Route of Infection Influences the Contribution of Key Immunity Genes to Antibacterial Defense in Anopheles gambiae.Journal of innate immunity · 2021Article
- Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.Frontiers in immunology · 2021Review
- Widely Used Mutants ofG3 (Bethesda, Md.) · 2020Article
- Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.Scientific reports · 2020Article
- Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment.PLoS genetics · 2019Article
- Review
- High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes.Communications biology · 2019Article
- Drosophila melanogaster as a polymicrobial infection model for Pseudomonas aeruginosa and Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We showed previously that eiger, the Drosophila tumor necrosis factor homolog, contributes to the pathology induced by infection with Salmonella typhimurium. We were curious whether eiger is always detrimental in the context of infection or if it plays a role in fighting some types of microbes. We challenged wild-type and eiger mutant flies with a collection of facultative intracellular and extracellular pathogens, including a fungus and Gram-positive and Gram-negative bacteria. The response of eiger mutants divided these microbes into two groups: eiger mutants are immunocompromised with respect to extracellular pathogens but show no change or reduced sensitivity to facultative intracellular pathogens. Hence, eiger helps fight infections but also can cause pathology. We propose that eiger activates the cellular immune response of the fly to aid clearance of extracellular pathogens. Intracellular pathogens, which can already defeat professional phagocytes, are unaffected by eiger.
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Registered trials
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