ArticlePediatric nephrology (Berlin, Germany)2007
Progression of chronic renal failure in children with dysplastic kidneys.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people.Nature reviews. Nephrology · 2019Guideline
- Clinical practice recommendations for the care of infants with stage 5 chronic kidney disease (CKD5).Pediatric nephrology (Berlin, Germany) · 2013Guideline
- Predictors of chronic kidney diseases and kidney failure in patients with CAKUT: a cohort study.International urology and nephrology · 2026Article
- Clinical and prognostic characteristics of renal hypodysplasia in children: insights from a 10-year single-center cohort.Pediatric nephrology (Berlin, Germany) · 2026Article
- Development of clinical and laboratory biomarkers in an international cohort of 428 children with lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2024Article
- Plasma D-asparagine and the D/L-serine ratio reflect chronic kidney diseases in children regardless of physique.Amino acids · 2024Article
- Hypertension in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2024Article
- Early predictive factors for progression to kidney failure in infants with severe congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- Promising biomarkers in pediatric chronic kidney disease through the kaleidoscope of CAKUT background complexity.Pediatric nephrology (Berlin, Germany) · 2021Article
- Acute kidney injury in children with chronic kidney disease is associated with faster decline in kidney function.Pediatric nephrology (Berlin, Germany) · 2021Article
- HNF1B Mutations Are Associated With a Gitelman-like Tubulopathy That Develops During Childhood.Kidney international reports · 2019Article
- Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Long-term outcome in inherited nephrogenic diabetes insipidus.Clinical kidney journal · 2019Article
- Common clinical markers predict end-stage renal disease in children with obstructive uropathy.Pediatric nephrology (Berlin, Germany) · 2019Observational
- Management of Hypertension in CAKUT: Protective Factor for CKD.Frontiers in pediatrics · 2019Review
- Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders.Pediatric nephrology (Berlin, Germany) · 2018Article
- Clinical and diagnostic features of Bartter and Gitelman syndromes.Clinical kidney journal · 2018Article
- Non-Traditional Risk Factors of Albuminuria in the Pediatric Population: A Scoping Review.International journal of environmental research and public health · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to describe progression of chronic renal failure (CRF) in children with renal malformations and to study factors influencing this progression. We reviewed retrospectively 176 children with CRF secondary to renal dysplasia, reflux nephropathy or renal obstruction with at least 5 years of follow-up. Serum creatinine was recorded at least every third month, and an estimated glomerular filtration rate (eGFR) was calculated. Number of febrile urinary tract infections (UTI), blood pressure, albuminuria (UaUc), and number of functioning kidneys was also recorded. We found that the development of renal function could be separated into three time periods: (1) During the first years of life, 82% of the children showed early improvement of their kidney function, which lasted until a median age of 3.2 years (median improvement 6.3 ml/year). (2) From the age of 3.2 years until 11.4 years, 52.5% of the studied children showed a stable kidney function, whereas in 47.5%, kidney function immediately started to deteriorate. (3) Around puberty, 42.9% started deterioration in kidney function, whereas 57.1% even after puberty showed a stable function. Patients with UaUc >200 mg/mmol deteriorated faster (-6.5 ml/min per 1.73 m(2) per year compared with -1.5 ml/min per 1.73 m(2) per year) in those with UaUc <50 mg/mmol. Children with more than two febrile UTIs, hypertension or an eGFR at onset of less than 40 ml/min per 1.73 m(2) deteriorated faster than the others. Most children experienced early improvement of kidney function. The further prognosis, early or late deterioration of kidney function or stable function during the whole follow-up, was related to albuminuria, number of febrile UTIs, eGFR at onset of deterioration, hypertension and puberty.
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