ArticlePharmaceutical research2007
Longitudinal analysis of gene expression in porcine skeletal muscle after post-injection local injury.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Preparation of Aditoprim Injection againstPharmaceutics · 2022Article
- Into the spotlight: RGK proteins in skeletal muscle.Cell calcium · 2021Review
- Extracellular matrix at the muscle - tendon interface: functional roles, techniques to explore and implications for regenerative medicine.Connective tissue research · 2021Review
- Impact of intramuscular administration of lipid-soluble and water-soluble vehicles into regenerating muscle at the distinct phases of skeletal muscle regeneration.The journal of physiological sciences : JPS · 2018Article
- Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds.BMC genomics · 2015Article
- Stem cell activation in skeletal muscle regeneration.Cellular and molecular life sciences : CMLS · 2015Review
- Satellite cells and the muscle stem cell niche.Physiological reviews · 2013Review
- Analysis of high dimensional data using pre-defined set and subset information, with applications to genomic data.BMC bioinformatics · 2012Article
- Article
- Analysis of Correlated Gene Expression Data on Ordered Categories.Journal of the Indian Society of Agricultural Statistics. Indian Society of Agricultural Statistics · 2010Article
- Secreted protein acidic and rich in cysteine (SPARC) in human skeletal muscle.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Cellular signalling · 2008Review
- A pig multi-tissue normalised cDNA library: large-scale sequencing, cluster analysis and 9K micro-array resource generation.BMC genomics · 2008Article
- The inflammatory response to skeletal muscle injury: illuminating complexities.Sports medicine (Auckland, N.Z.) · 2008Review
- Moderate Treadmill Training Induces Limited Effects on Quadriceps Muscle Hypertrophy in Mice Exposed to Cigarette Smoke Involving Metalloproteinase 2.International journal of chronic obstructive pulmonary diseaseArticle
- Role of matrix metalloproteinases in skeletal muscle: migration, differentiation, regeneration and fibrosis.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to describe the time course of gene expression in a skeletal muscle local injury induced by an intramuscular (IM) injection, and to compare the dynamics of gene expression with pathological events. MATERIALS AND
methodsTen piglets received 4 IM injections of propylene glycol in the longissimus dorsi muscles 6 h, 2, 7, and 21 days before euthanasia, where control and injected muscle sites were sampled for RNA isolation and microscopic examination. The hybridization of nylon cDNA microarrays was carried out with radioactive probes obtained from the muscle RNA.
results153 genes were found under- or over-expressed at least once among the investigated time-conditions. The eight most discriminant genes were also identified: Two genes (GTP-binding protein RAD and Ankyrin repeat domain protein) were over-expressed at 6 h and six genes between 2 and 21 days (Osteonectin, Fibronectin, Matrix metalloproteinase-2, Collagen alpha 1(I) chain, Collagen alpha 2(I) chain, and Thymosin beta-4). Necrosis, inflammation and regeneration were observed through both the dynamics of gene expression profiles and through the microscopic examinations.
conclusionOur data demonstrate that several pathways are involved in post-injection muscle injury, and that necrosis, inflammation and regeneration are not sequential but occur in parallel.
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