ArticleMolecular medicine (Cambridge, Mass.)
Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn's disease.Frontiers in immunology · 2026Article
- Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements.Frontiers in oncology · 2022Article
- Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells.Cold Spring Harbor perspectives in medicine · 2021Review
- Chronic Lymphocytic Leukemia.Cold Spring Harbor perspectives in medicine · 2021Review
- VDJSeq-Solver: in silico V(D)J recombination detection tool.PloS one · 2015Article
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- Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells.Immunogenetics · 2012Article
- Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.Molecular medicine (Cambridge, Mass.) · 2011Article
- Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells.PloS one · 2010Article
- Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders.Cancer science · 2009Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
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Abstract
Analyses of Ig V(H)DJ(H) rearrangements expressed by B-CLL cells have provided insights into the antigen receptor repertoire of B-CLL cells and the maturation stages of B-lymphocytes that give rise to this disease. However, less information is available about the L chain V gene segments utilized by B-CLL cells and to what extent their characteristics resemble those of the H chain. We analyzed the V(L) and J(L) gene segments of 206 B-CLL patients, paying particular attention to frequency of use and association, mutation status, and LCDR3 characteristics. Approximately 40% of B-CLL cases express V(L) genes that differ significantly from their germline counterparts. Certain genes were virtually always mutated and others virtually never. In addition, preferential pairing of specific V(L) and J(L) segments was found. These findings are reminiscent of the expressed VH repertoire in B-CLL. However unlike the V(H) repertoire, V(L) gene use was not significantly different than that of normal B-lymphocytes. In addition, Vkappa genes that lie more upstream on the germline locus were less frequently mutated than those at the 3' end of the locus; this was not the case for Vlambda genes and is not for V(H) genes. These similarities and differences between the IgH and IgL V gene repertoires expressed in B-CLL suggest some novel features while also reinforcing concepts derived from studies of the IgH repertoire.
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