ArticleMicrobiology (Reading, England)2007
Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism.
Article in Microbiology (Reading, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Allelic variations of intimin virulence gene (eae) in typical and atypical enteropathogenic Escherichia coli isolated from children with and without diarrhea in a rural area of southern Mozambique.BMC infectious diseases · 2026Article
- Distinct Tissue Localization and Transcriptional Profiles of Shiga Toxin-ProducingInternational journal of microbiology · 2026Article
- Growth dynamics and protein-expression of Escherichia coli serotypes O26:H11, O111:H8 and O145:NM in the bovine rumen.PloS one · 2025Article
- Comparative genomics of a novelMicrobial genomics · 2024Article
- Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Staying out or Going in? The Interplay between Type 3 and Type 5 Secretion Systems in Adhesion and Invasion of Enterobacterial Pathogens.International journal of molecular sciences · 2020Review
- Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.Cell metabolism · 2017Article
- Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection.Nature communications · 2015Article
- In vitro adhesion properties of Shiga toxin-producing Escherichia coli isolated from cattle, food, and humans.Frontiers in microbiology · 2015Article
- Article
- Potentially pathogenic Escherichia coli can form a biofilm under conditions relevant to the food production chain.Applied and environmental microbiology · 2014Article
- Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus.Frontiers in cellular and infection microbiology · 2014Review
- Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins.Applied and environmental microbiology · 2013Article
- EspA-Intimin chimeric protein, a candidate vaccine against Escherichia coli O157:H7.Iranian journal of microbiology · 2013Article
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections.Cold Spring Harbor perspectives in medicine · 2013Review
- Allele- and tir-independent functions of intimin in diverse animal infection models.Frontiers in microbiology · 2012Article
- Intestinal damage in enterohemorrhagic Escherichia coli infection.Pediatric nephrology (Berlin, Germany) · 2011Article
- Enterohemorrhagic Escherichia coli induce attaching and effacing lesions and hemorrhagic colitis in human and bovine intestinal xenograft models.Disease models & mechanisms · 2011Article
- Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization.Infection and immunity · 2008Article
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Authors and funding
6 authors.
Funding
Abstract
Intimin is an outer-membrane adhesin that is essential for colonization of the host gastrointestinal tract by attaching and effacing pathogens including enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR). The N-terminus of intimin from the different strains is highly conserved while the C-terminus, which harnesses the active receptor-binding site, shows sequence and antigenic polymorphism. This diversity was used to define a number of distinct intimin types, the most common of which are alpha, beta and gamma. Intimin binds the type III secretion system effector protein Tir. However, a large body of evidence suggests that intimin also binds a host-cell-encoded receptor(s) (Hir), and interaction of different intimin types with Hir contributes to tissue and host specificity. The aims of this study were to compare the activity of the major intimin types (alpha, beta and gamma) in vivo and ex vivo, using the CR mouse model and in vitro organ culture (IVOC), and to determine their exchangeability. The results confirm that intimin gamma is not functional in the CR mouse model. In the pig, intimin beta can substitute for EPEC intimin alpha but when placed in an EHEC O157 : H7 background it does not produce an intimin alpha-like tropism, although some adhesion to the small and large intestine was observed. In contrast, in human IVOC, intimin beta in an EHEC background produces small intestinal colonization in a similar manner to intimin alpha.
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