ArticleThe Journal of physiology2007
Intrinsic properties and mechanisms of spontaneous firing in mouse cerebellar unipolar brush cells.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- HCN1 is a primary HCN Pacemaker Channel in Neurons.Nature communications · 2026Article
- A Continuum of Response Properties across the Population of Unipolar Brush Cells in the Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Constructing functional models from biophysically-detailed neurons.PLoS computational biology · 2022Article
- Article
- N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels.British journal of pharmacology · 2020Article
- A comparative approach to cerebellar function: insights from electrosensory systems.Current opinion in neurobiology · 2016Review
- Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit.eLife · 2016Article
- Early Impairment of Synaptic and Intrinsic Excitability in Mice Expressing ALS/Dementia-Linked Mutant UBQLN2.Frontiers in cellular neuroscience · 2016Article
- In vivo differences in inputs and spiking between neurons in lobules VI/VII of neocerebellum and lobule X of archaeocerebellum.Cerebellum (London, England) · 2015Article
- Commentary on "E. Mugnaini and A. Floris, the unipolar brush cell: a neglected neuron of the mammalian cerebellar cortex. J Comp Neurol, 339:174-180, 1994".Cerebellum (London, England) · 2015Article
- Forward signaling by unipolar brush cells in the mouse cerebellum.Cerebellum (London, England) · 2015Article
- Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Resurgent current of voltage-gated Na(+) channels.The Journal of physiology · 2014Review
- Variable timing of synaptic transmission in cerebellar unipolar brush cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A temporal basis for predicting the sensory consequences of motor commands in an electric fish.Nature neuroscience · 2014Article
- Computational modeling predicts the ionic mechanism of late-onset responses in unipolar brush cells.Frontiers in cellular neuroscience · 2014Article
- Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum.PloS one · 2014Article
- Late-onset bursts evoked by mossy fibre bundle stimulation in unipolar brush cells: evidence for the involvement of H- and TRP-currents.The Journal of physiology · 2013Article
- Electrophysiological, morphological, and topological properties of two histochemically distinct subpopulations of cerebellar unipolar brush cells.Cerebellum (London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal firing patterns are determined by the cell's intrinsic electrical and morphological properties and are regulated by synaptic interactions. While the properties of cerebellar neurons have generally been studied in much detail, little is known about the unipolar brush cells (UBCs), a type of glutamatergic interneuron that is enriched in the granular layer of the mammalian vestibulocerebellum and participates in the representation of head orientation in space. Here we show that UBCs can be distinguished from adjacent granule cells on the basis of differences in membrane capacitance, input resistance and response to hyperpolarizing current injection. We also show that UBCs are intrinsically firing neurons. Using action potential clamp experiments and whole-cell recordings we demonstrate that two currents contribute to this property: a persistent TTX-sensitive sodium current and a ruthenium red-sensitive, TRP-like cationic current, both of which are active during interspike intervals and have reversal potentials positive to threshold. Interestingly, although UBCs are also endowed with a large I(h) current, this current is not involved in their intrinsic firing, perhaps because it activates at voltages that are more hyperpolarized than those associated with autonomous activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.