ReviewSteroids2007
Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications.
Review in Steroids, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 323 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
323 citing papers in PubMed, 5 syntheses or guidelines pooled it, 621 citations in OpenAlex.
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- The role of microRNAs in understanding sex-based differences in Alzheimer's disease.Biology of sex differences · 2024Pooled it
- Pooled it
- Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China.BMJ open · 2021Pooled it
- Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer's disease risk: a systematic review and meta-analysis involving 11,051 subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Baseline Variables Associated with Functional Decline in 2CARE, A Randomized Clinical Trial in Huntington's Disease.Journal of Huntington's disease · 2020Trial
- Decompressive craniectomy and expansive duraplasty with evacuation of hypertensive intracerebral hematoma, a randomized controlled trial.Neurosurgical review · 2017Trial
- Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life.Journal of the American Geriatrics Society · 2016Trial
- Prospective study of reproductive span and menopausal hormone therapy and cognitive decline over 8 years in the Nurses' Health Study.Menopause (New York, N.Y.) · 2026Article
- Associations of Hysterectomy and Oophorectomy with Dementia Risk: A Systematic Review and Meta-Analysis of Observational Studies.Journal of clinical medicine · 2026Article
- Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging.Annals of neurology · 2026Article
- Targeting hormone treatment for the brain in menopause.Scientific reports · 2026Article
- Ischemic Stroke Increases Protein Expression of the Folate Receptor and One-carbon Enzymes in Brain Tissue From Male and Female Patients.Translational stroke research · 2026Article
- Sex difference in Parkinson's disease hospitalization rates in Brazil (2010-2024).BMC neurology · 2026Article
- Migraine and menopause as converging factors in brain vulnerability: a hypothesis-driven perspective.The journal of headache and pain · 2026Review
- S-equol Modulates T3-Induced Transcription and Neurite Outgrowth in Neuronal Cells.International journal of molecular sciences · 2026Article
- Article
- Role of GSK-3 Inhibition in Alzheimer's Disease Therapy.Current Alzheimer research · 2026Review
- Article
- Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility.Frontiers in neuroscience · 2026Review
263 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the Women's Health Initiative (WHI) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.