ReviewPediatric nephrology (Berlin, Germany)2007
BK virus infection, replication, and diseases in pediatric kidney transplantation.
Review in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- BK polyomavirus genotype IV isolates from virus-specific T-cell therapy recipients.Microbiology resource announcements · 2025Article
- Single-nucleotide polymorphisms within the BK polyomavirus non-coding control region are genotype-associated.Microbiology spectrum · 2025Article
- Management strategies for common viral infections in pediatric renal transplant recipients.World journal of transplantation · 2024Review
- BK virus infection and outcome following kidney transplantation in childhood.Scientific reports · 2021Article
- Higher Incidence of BK Virus Nephropathy in Pediatric Kidney Allograft Recipients with Alport Syndrome.Journal of clinical medicine · 2019Article
- Non-immunologic allograft loss in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2019Review
- Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients.PloS one · 2017Observational
- Native kidney BK virus nephropathy associated with acute lymphocytic leukemia.Pediatric nephrology (Berlin, Germany) · 2013Article
- Immunity to Polyomavirus BK Infection: Immune Monitoring to Regulate the Balance between Risk of BKV Nephropathy and Induction of Alloimmunity.Clinical & developmental immunology · 2013Review
- Immunophenotyping in BK virus allograft nephropathy distinct from acute rejection.Clinical & developmental immunology · 2013Article
- Rare presentation of BK encephalitis in a child: imaging and pathological findings.Pediatric radiology · 2012Article
- Adaptive immunity rather than viral cytopathology mediates polyomavirus-associated nephropathy in mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Monitoring and managing viral infections in pediatric renal transplant recipients.Pediatric nephrology (Berlin, Germany) · 2012Review
- The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment.Pediatric nephrology (Berlin, Germany) · 2011Review
- Survival in pediatric dialysis and transplant patients.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- BK nephropathy in pediatric hematopoietic stem cell transplant recipients.Pediatric transplantation · 2009Article
- Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker.Pediatric nephrology (Berlin, Germany) · 2009Article
- A truncated T antigen expressed from an alternatively spliced BK virus early mRNA.The Journal of general virology · 2009Article
- High frequency and diversity of rearrangements in polyomavirus bk noncoding regulatory regions cloned from urine and plasma of Israeli renal transplant patients and evidence for a new genetic subtype.Journal of clinical microbiology · 2009Article
- Does a new polyomavirus contribute to Merkel cell carcinoma?Genome biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyomavirus-associated nephropathy is diagnosed in 2-8% of pediatric renal transplants and often precedes renal allograft dysfunction. Without intervention, however, significant graft dysfunction is observed in more than 50% of cases, although progressive early graft loss is reported in only three of 32 (9%) of cases. No specific treatment is available, but early decrease in immunosuppression is followed by declining human polyomavirus type 1 (BK virus) replication and improved outcome. The data suggest differences between pediatric and adult kidney transplantation. Possibly, pediatric patients might be able to mount a more vigorous BK virus-specific immune response than adult patients under similar modulation of immunosuppression. Also the role of cidofovir and leflunomide is still unresolved in pediatric patients. Larger prospective trials are needed to better define the impact of BK virus immunity for replication and disease as well as the role of reducing immunosuppression with or without cidofovir or leflunomide in pediatric transplant patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.