ArticleVirchows Archiv : an international journal of pathology2007
Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 43 citations in OpenAlex.
- A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression.Virchows Archiv : an international journal of pathology · 2024Article
- A large-scale clinicopathological and long-term follow-up study of solid papillary carcinoma of the breast.Virchows Archiv : an international journal of pathology · 2023Article
- Breast carcinomas of low malignant potential.Virchows Archiv : an international journal of pathology · 2022Review
- Papillary neoplasms of the breast-reviewing the spectrum.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast.SAGE open medicine · 2018Article
- A rare mixed breast cancer of intraductal and solid papillary with tubular carcinoma histotypes in a young woman.Journal of thoracic disease · 2017Article
- Invasive papillary breast carcinoma, solid variant with neuroendocrine differentiation.Turkish journal of surgery · 2017Article
- [Papillary lesions of the breast].Der Pathologe · 2014Review
- Papillary carcinoma of the breast: an overview.Breast cancer research and treatment · 2010Review
- Myoepithelial Carcinoma: A Rare Neoplasm of the Breast.Breast care (Basel, Switzerland) · 2010Article
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Authors and funding
7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We examined myoepithelial status in intraductal papillary carcinoma (IPC) along with the expression of high-molecular weight cytokeratin (HMWK) and neuroendocrine markers, with special reference to the differential diagnosis of solid intraductal papillary carcinoma(SIPC) and intraductal papilloma with usual ductal hyperplasia (IP-UDH). Twenty-six (93%) of the twenty-eight intraductal papillomas (IP) had myoepithelial cells in >70% of the epithelial-stromal interface of the intraluminal proliferating component. Six (29%) of twenty-one SIPC had almost complete myoepithelial layer like IP-UDH at the epithelial-stromal interface. HMWK (34 beta E-12) was diffusely positive in 14 (93%) of 15 IP-UDH, but 16 (76%) of 21 SIPC were completely negative for HMWK. Neuroendocrine markers were positive in 14 (67%) of SIPC, but all 28 IPs were completely negative. If only the presence of myoepithelial cells is emphasized as a benign hallmark, about 30% of SIPCs may be underdiagnosed as IP-UDH. However, by using a combination of myoepithelial markers, HMWK, and neuroendocrine markers, all of the 36 solid intraductal papillary lesions were properly classified as benign and malignant. Solid intraductal papillary lesions meeting at least two of the following criteria are highly likely to be malignant: (1) absence of myoepithelial cells(<10% of epithelial-stromal interface of intraluminal proliferating component), (2) negative HMWK(<10%), (3) positive neuroendocrine markers (>10%).
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